Ikuya Kimura
Fukuoka University
11 Papers
16 Citations
Ikuya Kimura is an academic researcher from Fukuoka University. The author has contributed to research in topics: Blood–brain barrier & Thrombin. The author has an hindex of 7, co-authored 10 publications.
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Papers
Activation of the α7 nicotinic acetylcholine receptor upregulates blood-brain barrier function through increased claudin-5 and occludin expression in rat brain endothelial cells.
Ikuya Kimura,Shinya Dohgu,Fuyuko Takata,Junichi Matsumoto,Yohei Kawahara,Megumi Nishihira,Shohei Sakada,Takuya Saisho,Atsushi Yamauchi,Yasufumi Kataoka +9 more
TL;DR: Findings suggest that the selective activation of α7 nAChRs on BECs has a specific role in upregulating BBB properties through increased claudin-5 and occludin expression.
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Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model.
Takashi Machida,Fuyuko Takata,Junichi Matsumoto,Tomoyuki Miyamura,Ryosuke Hirata,Ikuya Kimura,Yasufumi Kataoka,Shinya Dohgu,Atsushi Yamauchi +8 more
TL;DR: The brain pericyte–thrombin interaction may play a key role in causing BBB dysfunction in obesity-associated diabetes and represent a therapeutic target for its CNS complications.
Oncostatin-M-Reactive Pericytes Aggravate Blood-Brain Barrier Dysfunction by Activating JAK/STAT3 Signaling In Vitro.
Fuyuko Takata,Shinya Dohgu,Shinya Sakaguchi,Kenta Sakai,Gaku Yamanaka,Takuro Iwao,Junichi Matsumoto,Ikuya Kimura,Yume Sezaki,Yoshie Tanaka,Atsushi Yamauchi,Yasufumi Kataoka +11 more
TL;DR: Results suggest that OSM-reactive pericytes may have to be considered a characteristic machinery in the formation and progression of BBB breakdown under pathological conditions associated with increased OSM levels.
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Oncostatin M-induced blood-brain barrier impairment is due to prolonged activation of STAT3 signaling in vitro.
Fuyuko Takata,Shinya Dohgu,Junichi Matsumoto,Takashi Machida,Shinya Sakaguchi,Ikuya Kimura,Atsushi Yamauchi,Yasufumi Kataoka +7 more
TL;DR: Elevated OSM levels and activation of brain endothelial JAK/STAT3 signaling pathway under pathological conditions should be considered as a possible hallmark for induction and development of BBB impairment.
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Serum amyloid A-induced blood-brain barrier dysfunction associated with decreased claudin-5 expression in rat brain endothelial cells and its inhibition by high-density lipoprotein in vitro.
Junichi Matsumoto,Shinya Dohgu,Fuyuko Takata,Takuro Iwao,Ikuya Kimura,Misaki Tomohiro,Kentaro Aono,Yasufumi Kataoka,Atsushi Yamauchi +8 more
TL;DR: It is suggested that HDL counteracts the effects of SAA on BBB function, therefore, the functional imbalance between SAA and HDL may induce BBB impairment, thereby triggering development of neuroinflammation.
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