Iker Antón
University of Navarra
13 Papers
11 Citations
Iker Antón is an academic researcher from University of Navarra. The author has contributed to research in topics: Metastasis & Bone metastasis. The author has an hindex of 9, co-authored 13 publications.
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Papers
Inhibition of Collagen Receptor Discoidin Domain Receptor-1 (DDR1) Reduces Cell Survival, Homing, and Colonization in Lung Cancer Bone Metastasis
Karmele Valencia,Cristina Ormazábal,Carolina Zandueta,Diego Luis-Ravelo,Iker Antón,Maria J. Pajares,Jackeline Agorreta,Luis M. Montuenga,Susana Martínez-Canarias,Birgit Leitinger,Fernando Lecanda +10 more
TL;DR: In a model of tumor metastasis to bone, lack of DDR1 showed decreased metastatic activity associated with reduced tumor burden and osteolytic lesions, suggesting impaired colonization ability that was highly dependent on the bone microenvironment.
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Receptor of Activated Protein C Promotes Metastasis and Correlates with Clinical Outcome in Lung Adenocarcinoma
Iker Antón,Eva Molina,Diego Luis-Ravelo,Carolina Zandueta,Karmele Valencia,Cristina Ormazábal,Susana Martínez-Canarias,Naiara Perurena,Maria J. Pajares,Jackeline Agorreta,Luis M. Montuenga,Victor Segura,Ignacio I. Wistuba,Javier De Las Rivas,José Hermida,Fernando Lecanda +15 more
TL;DR: EPCR and its ligand APC promote cell survival that contributes to tumor cell endurance to stress favoring prometastatic activity of lung adenocarcinoma and is a novel target of relevance in the clinical outcome of early-stage lung cancer.
Tumor–stromal interactions of the bone microenvironment: in vitro findings and potential in vivo relevance in metastatic lung cancer models
Diego Luis-Ravelo,Iker Antón,Silvestre Vicent,Silvestre Vicent,Igor Hernández,Karmele Valencia,Carolina Zandueta,Susana Martínez-Canarias,Alfonso Gurpide,Fernando Lecanda +9 more
TL;DR: Results suggest subtle differences in the mechanisms of bone colonization for each lung cancer subtype, but share, although each to a different degree, dual MMP and osteoclastogenic activities that are differentially enhanced upon tumor–stromal interactions.
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Las metástasis óseas del cáncer
Silvestre Vicent,Diego Luis-Ravelo,Iker Antón,I. Hernández,S. Martínez,J. De Las Rivas,J. De Las Rivas,Alfonso Gurpide,Fernando Lecanda +8 more
TL;DR: Basic research will improve understanding of the basic mechanisms and lead to the clarification of molecular targets that will help in the development of medicines capable of preventing, decreasing or blocking the metastatic process.
Las metástasis óseas del cáncer Bone metastases
S. Vicent,Iker Antón,I. Hernández,S. Martínez,Fernando Lecanda +4 more
- 01 Jan 2006
TL;DR: Basic research will improve understanding of the basic mechanisms and lead to the clarification of molecular targets that will help in the development of medicines capable of pre- venting, decreasing or blocking the metastatic process.
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