Ihor R. Lemischka
Icahn School of Medicine at Mount Sinai
165 Papers
2.6K Citations
Ihor R. Lemischka is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Stem cell & Cellular differentiation. The author has an hindex of 61, co-authored 162 publications. Previous affiliations of Ihor R. Lemischka include United States Department of Veterans Affairs & University of Minnesota.
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Papers
Stem Cells and Their Niches
TL;DR: The stem cell niche concept is discussed, recent progress is highlighted, and important unanswered questions are identified.
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A Stem Cell Molecular Signature
Natalia Ivanova,John T. Dimos,Christoph Schaniel,Jason A. Hackney,Kateri A. Moore,Ihor R. Lemischka +5 more
TL;DR: This work determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopolietic hierarchy, which define key conserved regulatory pathways in this developmental system.
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Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
Xonia Carvajal-Vergara,Ana Sevilla,Sunita L. D’Souza,Yen-Sin Ang,Christoph Schaniel,Dung Fang Lee,Lei Yang,Aaron D. Kaplan,Eric Adler,Roye Rozov,Yongchao Ge,Ninette Cohen,Lisa Edelmann,Betty Chang,Avinash Waghray,Jie Su,Sherly Pardo,Klaske D. Lichtenbelt,Marco Tartaglia,Bruce D. Gelb,Ihor R. Lemischka +20 more
TL;DR: In vitro-derived cardiomyocytes from LEOPARD syndrome iPSCs are larger, have a higher degree of sarcomeric organization and preferential localization of NFATC4 in the nucleus when compared with cardiomeocytes derived from human embryonic stem cells or wild-type iPSC derived from a healthy brother of one of the LEopARD syndrome patients, which correlate with a potential hypertrophic state.
761
The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells
Qin Shen,Yue Wang,John T. Dimos,Christopher A. Fasano,Timothy N. Phoenix,Ihor R. Lemischka,Natalia Ivanova,Stefano Stifani,Edward E. Morrisey,Sally Temple +9 more
TL;DR: It is shown in mice that the essential timing mechanism is programmed within individual progenitor cells, and its expression depends solely on cell-intrinsic and environmental factors generated within the clonal lineage.
670
A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.
William Matthews,Craig T. Jordan,Marc Gavin,Nancy A. Jenkins,Neal G. Copeland,Ihor R. Lemischka +5 more
TL;DR: In this paper, a fetal liver kinase 1 (Flk-1) was cloned from mouse cell populations enriched for hematopoietic stem and progenitor cells.
639