Igor Tamm
Rockefeller University
202 Papers
4.7K Citations
Igor Tamm is an academic researcher from Rockefeller University. The author has contributed to research in topics: Virus & RNA. The author has an hindex of 52, co-authored 201 publications. Previous affiliations of Igor Tamm include Rockefeller Institute of Government.
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Papers
Inhibition of Synchronized Cellular Deoxyribonucleic Acid Synthesis During Newcastle Disease Virus, Mengovirus, or Reovirus Infection
William D. Ensminger,Igor Tamm +1 more
TL;DR: Colorimetric determinations of the amounts of DNA produced in synchronized cells have substantiated the inhibition of DNA synthesis observed by isotope incorporation techniques, indicating that DNA synthesis in early S phase is relatively insensitive to the inhibitory function of reovirus.
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An evaluation of messenger RNA competition in the shutoff of human interferon production.
Pravinkumar B. Sehgal,Igor Tamm +1 more
TL;DR: The process that shuts off poly(I)-poly(C)-induced interferon production in a strain of diploid human fibroblasts (FS-4)-involves the synthesis of new RNA, presumably nuclear heterogeneous RNA.
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Regulation of human interferon production: II. Inhibition of interferon messenger RNA synthesis by 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole
TL;DR: Polyinosinic:polycytidylic acid-induced synthesis of interferon messenger RNA in a strain of diploid human fibroblasts can be inhibited by 5,6-dichloro-1-β- d -ribofuranosylbenzimidazole (DRB).
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Distribution and translation of poliovirus RNA in guanidine-treated cells.
Lawrence A. Caliguiri,Igor Tamm +1 more
TL;DR: Guanidine inhibits viral RNA synthesis more rapidly than viral protein synthesis in poliovirus-infected HeLa cells and no viral RNA is detected in the replication complex 10 minutes after addition of guanidine, suggesting that viral RNA molecules are released from the replicationcomplex after completion.
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Synthesis and Virus-inhibitory Activity of D - and L -Isomers of 2-(α-Hydroxybenzyl)- benzimidazole
TL;DR: The virus-inhibitory activity of the optical isomers of HBB is determined, which is shown to inhibit the synthesis of virus-directed RNA polymerase, of viral RNA5–7 and viral coat protein5.
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