46 Papers
224 Citations
Igor Shevchuk is an academic researcher from National Institute of Chemical Physics and Biophysics. The author has contributed to research in topics: Mitochondrion & Oxidative phosphorylation. The author has an hindex of 17, co-authored 44 publications. Previous affiliations of Igor Shevchuk include Tallinn University of Technology.
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Papers
Systems bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine in regulation of cardiac cell function
Rita Guzun,Natalja Timohhina,Kersti Tepp,Marcela Gonzalez-Granillo,Igor Shevchuk,Vladimir Chekulayev,A.V. Kuznetsov,Tuuli Kaambre,Valdur Saks,Valdur Saks +9 more
TL;DR: Experimental studies have revealed that PCr may play two important roles in the regulation of muscle energetics: first by maintaining local ATP pools via compartmentalized creatine kinase reactions, and secondly by stabilizing cellular membranes due to electrostatic interactions with phospholipids.
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Metabolic remodeling in human colorectal cancer and surrounding tissues: alterations in regulation of mitochondrial respiration and metabolic fluxes.
Vladimir Chekulayev,Kati Mado,Igor Shevchuk,Andre Koit,Andrus Kaldma,Aleksandr Klepinin,Natalja Timohhina,Kersti Tepp,Manana Kandashvili,Lyudmila Ounpuu,Karoliina Heck,Laura Truu,Anu Planken,Vahur Valvere,Tuuli Kaambre,Tuuli Kaambre +15 more
TL;DR: Experiments showed that human CRC cannot be considered a hypoxic tumor, since the malignancy itself and cells surrounding it exhibited even higher rates of OXPHOS than healthy large intestine.
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Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation
Rita Guzun,Tuuli Kaambre,Rafaela Bagur,Alexei Grichine,Yves Usson,Minna Varikmaa,Tiia Anmann,Kersti Tepp,Natalja Timohhina,Igor Shevchuk,Vladimir Chekulayev,François Boucher,P. Dos Santos,Uwe Schlattner,Theo Wallimann,A.V. Kuznetsov,Petras P. Dzeja,Mayis Aliev,Valdur Saks +18 more
TL;DR: Regulation of mitochondrial ATP synthesis within ICEUs allowing heart workload to be linearly correlated with oxygen consumption ensuring conditions of metabolic stability, signal communication and synchronization is described.
Metabolic control analysis of cellular respiration in situ in intraoperational samples of human breast cancer
Tuuli Kaambre,Vladimir Chekulayev,Igor Shevchuk,Minna Karu-Varikmaa,Natalja Timohhina,Kersti Tepp,Jelena Bogovskaja,Riina Kütner,Vahur Valvere,Valdur Saks,Valdur Saks +10 more
TL;DR: The data support the two-compartment hypothesis of tumor metabolism, the high sum of FCC showing structural and functional organization of mitochondrial respiratory chain and ATP synthasome as supercomplexes in human BC.
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Hydrogen peroxide, superoxide, and hydroxyl radicals are involved in the phototoxic action of hematoporphyrin derivative against tumor cells.
TL;DR: It is found that photosensitization of EAC cells with HPD leads to the formation of significant amounts of H2O2, superoxide (O2-.), and hydroxyl (OH.) radicals, which along with 1O2 were involved in photoinactivation of the cells in vitro.
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