Igor Shapiro
Ludwig Maximilian University of Munich
16 Papers
90 Citations
Igor Shapiro is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Stem cell & Cellular differentiation. The author has an hindex of 8, co-authored 16 publications. Previous affiliations of Igor Shapiro include University of Freiburg.
Chat about Author
Papers
Side population does not define stem cell-like cancer cells in the adrenocortical carcinoma cell line NCI h295R.
Urs D Lichtenauer,Igor Shapiro,Klaus Geiger,Marcus Quinkler,Martin Fassnacht,Roland Nitschke,K. D. Rückauer,Felix Beuschlein,Felix Beuschlein +8 more
TL;DR: Findings provide evidence that Hoechst dye exclusion, in contrast to what has been reported for other tumor entities, is not a major tumor stem cell defining marker in adrenocortical NCI h295R tumor cells.
52
Gonadectomy in mice of the inbred strain CE/J induces proliferation of sub-capsular adrenal cells expressing gonadal marker genes
Inga Johnsen,Marc Slawik,Igor Shapiro,Michaela F. Hartmann,Stefan A. Wudy,Brendan D. Looyenga,Gary D. Hammer,Martin Reincke,Felix Beuschlein +8 more
TL;DR: Data suggest that adrenal tumors in gonad-ectomized CE/J mice are direct derivatives from cells of the proposed sub-capsular stem cell zone, consistent with a defect in the differentiation of these cells into a cell population with functional properties that otherwise define a gonadal endocrine phenotype.
37
Expression and spatio-temporal distribution of differentiation and proliferation markers during mouse adrenal development ☆
TL;DR: Findings are in accordance with the concept of distinct cell populations present during adrenocortical development with a highly proliferative phenotype or differentiated steroidogenic properties.
37
Aldosterone producing adrenal adenomas are characterized by activation of calcium/calmodulin-dependent protein kinase (CaMK) dependent pathways.
TL;DR: In this paper, aldosterone producing adenomas (APAs) were found to be significantly upregulated in the Calmodulin Kinase (CaMKI) pathway on the mRNA and protein level.
16
Identification of adrenal genes regulated in a potassium-dependent manner
Alexander Dierks,Urs D Lichtenauer,Simone Sackmann,Ariadni Spyroglou,Igor Shapiro,Marcel Geyer,Jenny Manonopoulou,Martin Reincke,Constanze Hantel,Felix Beuschlein +9 more
TL;DR: In this paper, the effects of chronic potassium substitution in mice were investigated, and the time dependency of expression changes of these pre-defined genes was studied following short-term potassium stimulation experiments in vivo.