Igor S. Tolokh
Virginia Tech
41 Papers
163 Citations
Igor S. Tolokh is an academic researcher from Virginia Tech. The author has contributed to research in topics: Magnetic field & Paramagnetism. The author has an hindex of 15, co-authored 32 publications. Previous affiliations of Igor S. Tolokh include National Academy of Sciences of Ukraine & University of Guelph.
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Papers
Charge hydration asymmetry: the basic principle and how to use it to test and improve water models
TL;DR: It is shown which electric multipole components of a water molecule are key to explain its ability for asymmetric charge hydration, and an analogue of the Born equation that includes the missing physics necessary to account for CHA is derived.
Opposing Effects of Multivalent Ions on the Flexibility of DNA and RNA
Aleksander Drozdetski,Igor S. Tolokh,Lois Pollack,Nathan A. Baker,Nathan A. Baker,Alexey V. Onufriev +5 more
TL;DR: Atomic molecular dynamics simulations are used to predict that multivalent counterions have the opposite effect on double-stranded RNA, increasing its bending rigidity by at least 30%.
Spermine Condenses DNA, but Not RNA Duplexes
Andrea M. Katz,Igor S. Tolokh,Suzette A. Pabit,Nathan A. Baker,Alexey V. Onufriev,Lois Pollack +5 more
TL;DR: The goal of this study is to explain how RNA can remain soluble and available for interaction with other molecules in the cell despite the presence of spermine at concentrations high enough to precipitate DNA.
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Introducing Charge Hydration Asymmetry into the Generalized Born Model.
TL;DR: CHA–GB employs a novel definition of the dielectric boundary that does not subsume the CHA effects into the intrinsic atomic radii, which leads to finding a new set of intrinsicatomic radii optimized for CHA–GB; these radii show physically meaningful variation with the atom type, in contrast to the radii set optimized for GB.
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Nature of the stacking interaction of nucleotide bases in water: a Monte Carlo study of the hydration of uracil molecule associates
TL;DR: The results of a Monte Carlo study of the hydration of a uracil molecule, its stacked and H-bonded dimers are presented in this paper, where it is shown that the formation of the stacked dimer is mainly governed by the energetically favorable change of water structure during the transition of monomers to dimers.
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