Igor Prudovsky
Maine Medical Center
109 Papers
1K Citations
Igor Prudovsky is an academic researcher from Maine Medical Center. The author has contributed to research in topics: Fibroblast growth factor & Notch signaling pathway. The author has an hindex of 36, co-authored 106 publications. Previous affiliations of Igor Prudovsky include University of Rochester & American Red Cross.
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Papers
Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction.
Adrián Ruiz-Villalba,Juan P. Romero,Silvia C. Hernandez,Amaia Vilas-Zornoza,Nikolaus Fortelny,Laura Castro-Labrador,Patxi San Martin-Uriz,Erika Lorenzo-Vivas,Paula García-Olloqui,Marcel Palacio,Juan José Gavira,Gorka Bastarrika,Stefan Janssens,Ming Wu,E. Iglesias,Gloria Abizanda,Xabier Martinez de Morentin,Miren Lasaga,Núria Planell,Christoph Bock,Christoph Bock,Diego Alignani,Gema Medal,Igor Prudovsky,Yong-Ri Jin,Sergey Ryzhov,Haifeng Yin,Beatriz Pelacho,David Gomez-Cabrero,Volkhard Lindner,David Lara-Astiaso,Felipe Prosper +31 more
TL;DR: This study identifies Cthrc1 as a novel regulator of the healing scar process, and as a target for future translational studies.
190
The non-classical export routes: FGF1 and IL-1α point the way
Igor Prudovsky,Anna Mandinova,Raffaella Soldi,Cinzia Bagalà,Irene Graziani,Matteo Landriscina,Francesca Tarantini,Maria F. Duarte,Stephen Bellum,Holly Doherty,Thomas Maciag +10 more
TL;DR: Non-classical protein release independent of the ER-Golgi pathway has been reported for an increasing number of proteins lacking an N-terminal signal sequence, and inhibition of their export by Cu2+ chelators is an effective strategy for treatment of several diseases.
Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome
Gloria Lopez-Castejon,Nadia Luheshi,Vincent Compan,Stephen High,Roger C. Whitehead,Sabine L. Flitsch,Aleksandr Kirov,Igor Prudovsky,Eileithyia Swanton,David Brough +9 more
TL;DR: The requirement for DUB activity in a key reaction of the innate immune response is revealed and the therapeutic potential of DUB inhibitors for chronic auto-inflammatory diseases is highlighted.
174
Secretion without Golgi
Igor Prudovsky,Francesca Tarantini,Matteo Landriscina,David J. Neivandt,Raffaella Soldi,Aleksandr Kirov,Deena Small,Karuppanan Muthusamy Kathir,Dakshinamurthy Rajalingam,Thallapuranam Krishnaswamy Suresh Kumar +9 more
TL;DR: Non‐classical release of FGF1 and IL1α presents a promising target for treatment of cardiovascular, oncologic, and inflammatory disorders.
Molecular Dependence of Estrogen Receptor–Negative Breast Cancer on a Notch-Survivin Signaling Axis
TL;DR: Activation of Notch developmental signaling in estrogen receptor (ER)-negative breast cancer cells results in direct transcriptional up-regulation of the apoptosis inhibitor and cell cycle regulator survivin, associated with increased expression of survivin at mitosis, enhanced cell proliferation, and heightened viability at cell division.
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