Igor Jurisica
University Health Network
354 Papers
2.1K Citations
Igor Jurisica is an academic researcher from University Health Network. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 73, co-authored 324 publications. Previous affiliations of Igor Jurisica include Structural Genomics Consortium & Brigham and Women's Hospital.
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Papers
The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions
Livia Perfetto,Chiara Pastrello,Noemi del-Toro,Margaret Duesbury,Margaret Duesbury,Marta Iannuccelli,Max Kotlyar,Luana Licata,Birgit H M Meldal,Kalpana Panneerselvam,Simona Panni,Negin Rahimzadeh,Sylvie Ricard-Blum,Lukasz Salwinski,Anjali Shrivastava,Gianni Cesareni,Matteo Pellegrini,Sandra Orchard,Igor Jurisica,Igor Jurisica,Henning Hermjakob,Pablo Porras +21 more
TL;DR: A curated dataset of physical molecular interactions, manually extracted by IMEx Consortium curators focused on proteins from SARS-CoV-2, Sars- coV-1 and other members of the Coronaviridae family is presented.
Fibrillin-1 (FBN-1) a new marker of germ cell neoplasia in situ.
Zuzana Cierna,Michal Mego,Igor Jurisica,Katarina Machalekova,Michal Chovanec,Viera Miskovska,Daniela Svetlovska,Katarina Kalavska,Katarina Rejlekova,Karol Kajo,Jozef Mardiak,Pavel Babal +11 more
TL;DR: FBN-1 is overexpressed in TGCTs and especially in GCNIS when compared to non-neoplastic testicular tissue in patients with germ cell tumors and could be involved in germ cell neoplasia in situ development.
Immune-enrichment of non-small cell lung cancer baseline biopsies for multiplex profiling define prognostic immune checkpoint combinations for patient stratification
Anne Monette,Derek Bergeron,Amira Ben Amor,Liliane Meunier,Christine Caron,Anne-Marie Mes-Masson,Nidhameddine Kchir,Kamel Hamzaoui,Igor Jurisica,Réjean Lapointe +9 more
TL;DR: Deepening the understanding of immune-checkpoint biology, comprehensive protein-protein interaction and pathway mapping revealed that redundant immune- checkpoint interactors associate with positive outcomes, providing new avenues for the deciphering of molecular mechanisms behind effects of immunotherapeutic agents targeting immune-checks.
Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma
Erin L. Stewart,Céline Mascaux,Nhu An Pham,Shingo Sakashita,Jenna Sykes,Lucia Kim,Naoki Yanagawa,Ghassan Allo,Kota Ishizawa,Dennis Wang,Chang-Qi Zhu,Ming Li,Christine Ng,Ni Liu,Melania Pintilie,Petra Martin,Thomas John,Igor Jurisica,Natasha B. Leighl,Benjamin G. Neel,Thomas K. Waddell,Frances A. Shepherd,Geoffrey Liu,Ming-Sound Tsao +23 more
TL;DR: PDX models closely recapitulate primary tumor biology and clinical outcome and may serve as important laboratory models to investigate mechanisms of resistance to targeted therapies, and for preclinical testing of novel treatment strategies.
Osteoarthritis Data Integration Portal (OsteoDIP): A web-based gene and non-coding RNA expression database
Chiara Pastrello,Mark Abovsky,Richard Lu,Zuhaib Ahmed,Max Kotlyar,Christian Veillette,Igor Jurisica +6 more
TL;DR: OsteoDIP as mentioned in this paper collects and provides, in a simple searchable format, curated high throughput RNA expression data related to osteoarthritis, including non-coding RNAs.