Igor Jurisica
University Health Network
354 Papers
2.1K Citations
Igor Jurisica is an academic researcher from University Health Network. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 73, co-authored 324 publications. Previous affiliations of Igor Jurisica include Structural Genomics Consortium & Brigham and Women's Hospital.
Chat about Author
Papers
Towards a unified open access dataset of molecular interactions
Pablo Porras,Elisabet Barrera,Alan Bridge,Noemi del-Toro,Gianni Cesareni,Margaret Duesbury,Margaret Duesbury,Henning Hermjakob,Marta Iannuccelli,Igor Jurisica,Igor Jurisica,Igor Jurisica,Max Kotlyar,Luana Licata,Ruth C. Lovering,David J. Lynn,Birgit H M Meldal,Bindu Nanduri,Kalpana Paneerselvam,Simona Panni,Chiara Pastrello,Matteo Pellegrini,Livia Perfetto,Negin Rahimzadeh,Prashansa Ratan,Sylvie Ricard-Blum,Lukasz Salwinski,Gautam Shirodkar,Anjalia Shrivastava,Sandra Orchard +29 more
TL;DR: This update to the work of the IMEx Consortium discusses how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats.
Gene Expression Profiling in Cervical Cancer: An Exploration of Intratumor Heterogeneity
Barbara Bachtiary,Paul C. Boutros,Melania Pintilie,W. Shi,Carlo Bastianutto,Jian-Hua Li,Joerg Schwock,Wendy Zhang,Linda Z. Penn,Igor Jurisica,Anthony Fyles,Fei-Fei Liu +11 more
TL;DR: Although the intratumor heterogeneity was low for the majority of the tested ProbeSets, for many genes, multiple biopsies are required to obtain a reliable estimate of gene expression.
Extracellular Matrix Injury of Kidney Allografts in Antibody-Mediated Rejection: A Proteomics Study.
Sergi Clotet-Freixas,Caitriona M. McEvoy,Ihor Batruch,Chiara Pastrello,Max Kotlyar,Julie Anh Dung Van,Julie Anh Dung Van,Madhurangi Arambewela,Alex Boshart,Alex Boshart,Sofia Farkona,Yun Niu,Yanhong Li,Olusegun Famure,Andrea Bozovic,Vathany Kulasingam,Peixuen Chen,S. Joseph Kim,Emilie Chan,S. Moshkelgosha,Syed Ashiqur Rahman,Jishnu Das,Tereza Martinu,Stephen C. Juvet,Igor Jurisica,Andrzej Chruscinski,Rohan John,Rohan John,Ana Konvalinka +28 more
TL;DR: Proteomic analysis performed on laser-captured and microdissected glomeruli and tubulointerstitium identified early ECM remodeling, which may represent a new therapeutic opportunity in chronic AMR.
In silico prediction of physical protein interactions and characterization of interactome orphans
Max Kotlyar,Chiara Pastrello,Flavia Pivetta,Alessandra Lo Sardo,Christian A. Cumbaa,Han Li,Taline Naranian,Yun Niu,Yun Niu,Zhiyong Ding,Fatemeh Vafaee,Fatemeh Vafaee,Fiona Broackes-Carter,Julia Petschnigg,Gordon B. Mills,Andrea Jurisicova,Igor Stagljar,Roberta Maestro,Igor Jurisica +18 more
TL;DR: This work introduces FpClass, a data mining–based method for proteome-wide PPI prediction, which predicted 250,498 PPIs among 10,531 human proteins; 10,647 PPIs involved 1,089 proteins without known interactions.
•Journal Article
Molecular profiling of non-small cell lung cancer and correlation with disease-free survival.
Dennis A. Wigle,Igor Jurisica,Niki Radulovich,Melania Pintilie,Janet Rossant,Ni Liu,Chao Lu,James R. Woodgett,Isolde Seiden,Michael R. Johnston,Shaf Keshavjee,Gail Darling,Timothy Winton,Bobby-Joe Breitkreutz,Paul Jorgenson,Mike Tyers,Frances A. Shepherd,Ming-Sound Tsao +17 more
TL;DR: Evidence is provided that molecular subtyping of NSCLC can identify distinct profiles of gene expression correlating with disease-free survival, and statistical analysis and clustering approaches were used to determine patterns of geneexpression segregating with clinical outcome.