Igor Helbrecht
University of Warsaw
5 Papers
Igor Helbrecht is an academic researcher from University of Warsaw. The author has contributed to research in topics: Cancer stem cell & Gene. The author has an hindex of 2, co-authored 3 publications.
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Papers
Current approaches in identification and isolation of human renal cell carcinoma cancer stem cells
Mohammed Imran Khan,Anna M. Czarnecka,Igor Helbrecht,Ewa Bartnik,Ewa Bartnik,Fei Lian,Cezary Szczylik +6 more
TL;DR: This review focuses on the strategies for sample preparation during flow cytometric analysis, elaborating biomarkers such as CXCR4, CD105, and CD133, and functional properties characteristic of CSCs/TICs using side population selection through Hoechst 33342 dye, aldehyde dehydrogenase 1, dye-cycle violet, and rhodamine 123.
Characterization of winged helix domain fusion endonucleases as N6-methyladenine-dependent type IV restriction systems
Igor Helbrecht,Daniel F. Heiter,Weiwei Yang,Tamas Vincze,Andrew Hanneman,Thomas Lutz,Laurence Ettwiller,Matthias Bochtler,Shuang-yong Xu +8 more
TL;DR: The role of the wH domain as a sensor of adenine methylation is widespread in prokaryotes and previously uncharacterized examples of PD-(D/E)XK—wH (FcyTI, Psp4BI), PUA—wH—HNH (HtuIII), wH—GIY-YIG (Ahi29725I, Apa233I), and PLD—wH (Aba4572I, Cba
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Prokaryotic winged helix domains as dsDNA adenine methylation sensors
Igor Helbrecht,Daniel F. Heiter,Weiwei Yang,Thomas Lutz,Laurence Ettwiller,Matthias Bochtler,Shuang-yong Xu +6 more
TL;DR: In this article , the role of the winged helix-turn-helix (wH) domains as a sensor of adenine methylation is demonstrated in prokaryotes.
Cancer stem cells in renal carcinoma
Łukasz Szymański,Igor Helbrecht,Michal Fiedorowicz,Damian Matak,Ewa Bartnik,Pawel Golik,Cezary Szczylik,Anna M. Czarnecka +7 more
TL;DR: This publication covers the role the CSCs and their origin in renal cell carcinoma, with particular emphasis on clear cell subtype.
Comparative Gene Expression Profiling of Primary and Metastatic Renal Cell Carcinoma Stem Cell-Like Cancer Cells
Mohammed Imran Khan,Anna M. Czarnecka,Sławomir Lewicki,Igor Helbrecht,Klaudia Brodaczewska,Irena Koch,Robert Zdanowski,Magdalena Król,Cezary Szczylik +8 more
TL;DR: The main goal of the project was to describe the gene-expression profile of stem cell-like cancer cells of primary tumor and metastatic origin, designed to verify the presence of SCLCCs in renal cell cancer cell lines.