Igor E. Makarenko
10 Papers
1 Citations
Igor E. Makarenko is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea
Olga N. Pozharitskaya,Alexander N. Shikov,Into Laakso,Tuulikki Seppänen-Laakso,Igor E. Makarenko,N.M. Faustova,Marina N. Makarova,Valery G. Makarov +7 more
TL;DR: The results suggest that sea urchin gonads may serve as a functional food for the management of inflammatory diseases and diabetes.
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Comparability of biosimilar romiplostim with originator: Protein characterization, animal pharmacodynamics and pharmacokinetics.
Anna N. Arefeva,Igor E. Makarenko,Valeria B. Saparova,Dzhina D. Karal-ogli,Alina N. Afanaseva,A. Dorotenko,A. V. Kalatanova,D. V. Kurkin,A. L. Khokhlov,Roman V. Drai +9 more
TL;DR: The results of preclinical studies of romiplostim analogue GP40141 are presented in this article , where the effect of a cell proliferation, phosphorylation of the TPO receptor and JAK2 phosphorylated were studied in the presence of romplostim and in the absence of GP401 41 in a cell line of mice (Mus musculus) lymphoblasts with stable expression of human TPO receptors 32D-hTPOR clone 63.
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Modern concepts of the pathogenesis of type 2 diabetes mellitus
D. V. Kurkin,E. I. Morkovin,D. A. Bakulin,Yulia S. Gorbunova,A. V. Strygin,A. Robertus,Igor E. Makarenko,Valeria B. Saparova,Roman V. Drai,Vladimir Petrov +9 more
TL;DR: In this paper , the authors presented the concept of normal glucose metabolism, the role of the loss of functional mass of p-cells, aspects of the synthesis and metabolism of glucose by the liver, role of muscle tissue in the consumption of glucose, as well as the roles of the kidneys in the development of a vicious circle of diabetic hyperglycemia.
Physiology, pharmacology and prospects for dipeptidilpeptidase-4 inhibitors use
D. V. Kurkin,D. A. Bakulin,E. I. Morkovin,A. V. Strygin,Yulia S. Gorbunova,E. V. Volotova,Igor E. Makarenko,Valeria B. Saparova,Roman V. Drai,Vladimir Petrov +9 more
TL;DR: In this paper , the authors analyzed the literature data on the therapeutic potential and results of the DPP-4 inhibitors research and found that DPP inhibitors reduce an enzyme activity by 70-90%, increasing plasma incretin levels by 2-4 times and have been used to treat DM2 since 2006.
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Modeling of Pharmacokinetic Profiles of Insulin Aspart and Biphasic Insulin Aspart 30/70
TL;DR: The developed PK model allows us to predict PK profiles for various doses and formulations of insulin aspart and can be used to improve the accuracy, safety, and ethics of novel clinical trials of insulin.
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