Ignacio Marcelo Helbling
National University of the Littoral
19 Papers
44 Citations
Ignacio Marcelo Helbling is an academic researcher from National University of the Littoral. The author has contributed to research in topics: Controlled release & Chemistry. The author has an hindex of 9, co-authored 19 publications.
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Papers
Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling
Carlos Alberto Busatto,Juan Ignacio Pesoa,Ignacio Marcelo Helbling,Julio Alberto Luna,Diana Alejandra Estenoz +4 more
TL;DR: A mathematical model was developed that predicts the progesterone release profiles from different-sized PLGA microspheres, which takes into account both the dissolution and diffusion of the drug in the polymeric matrix as well as the autocatalytic effect of polymer degradation.
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The Optimization of an Intravaginal Ring Releasing Progesterone Using a Mathematical Model
TL;DR: EVA rings could be designed to release progesterone in vitro at a rate of 12.05 ± 8.91 mg day−1, similar to that observed for Progering®, and could be used in contraception therapies during lactation.
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Recent advances in chitosan films for controlled release of drugs.
TL;DR: This work highlights the use of chitosan in the film technology for drug delivery, presenting examples of ch itosan used in an unmodified state and examples of modifications of the polymer backbone.
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Mathematical modeling of drug delivery from torus-shaped single-layer devices
TL;DR: A mathematical modeling of controlled release of drug from torus-shaped single-layer devices is presented and a good agreement between the model prediction and the experimental data is observed.
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Preparation of TPP-crosslinked chitosan microparticles by spray drying for the controlled delivery of progesterone intended for estrus synchronization in cattle
Ignacio Marcelo Helbling,Carlos Alberto Busatto,Silvana Alejandra Fioramonti,Juan Ignacio Pesoa,Liliana G. Santiago,Diana Alejandra Estenoz,Julio Alberto Luna +6 more
TL;DR: The mathematical model developed can help to find proper particle features to reach specific delivery rates in the animals and not only save time, money and effort but also minimized experimentation with animals which is desired from an ethical point of view.
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