Ida E. Andersson
Lund University
7 Papers
75 Citations
Ida E. Andersson is an academic researcher from Lund University. The author has contributed to research in topics: Glycopeptide & Major histocompatibility complex. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Ida E. Andersson include Umeå University.
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Papers
Postprocessing of docked protein-ligand complexes using implicit solvation models.
Anton Lindström,Lotta Edvinsson,Andreas Johansson,C. David Andersson,Ida E. Andersson,Florian Raubacher,Anna Linusson +6 more
TL;DR: The results indicate that the protocol for the postprocessing of docked protein-ligand complexes developed in this paper may be generally useful for structure-based design in drug discovery.
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Oxazole-modified glycopeptides that target arthritis-associated class II MHC Aq and DR4 proteins
Ida E. Andersson,Tsvetelina Batsalova,Balik Dzhambazov,Lotta Edvinsson,Rikard Holmdahl,Jan Kihlberg,Jan Kihlberg,Anna Linusson +7 more
TL;DR: This work contributes to the development of an altered glycopeptide for inducing immunological tolerance in CIA, with the long-term goal of developing a therapeutic vaccine for treatment of RA.
Probing molecular interactions within class II MHC Aq/glycopeptide/T-cell receptor complexes associated with collagen-induced arthritis.
TL;DR: T cells obtained in a mouse model for rheumatoid arthritis are activated by a glycopeptide fragment from rat type II collagen bound to the class II major histocompatibility complex Aq molecule, and recognition by a panel of T-cell hybridomas revealed high sensitivity for the backbone modifications.
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Design of Glycopeptides Used to Investigate Class II MHC Binding and T-Cell Responses Associated with Autoimmune Arthritis
Ida E. Andersson,C. David Andersson,Tsvetelina Batsalova,Balik Dzhambazov,Rikard Holmdahl,Jan Kihlberg,Jan Kihlberg,Anna Linusson +7 more
TL;DR: The SAR understanding obtained in this study provides a platform for the design of second-generation glycopeptides with tuned MHC affinities and T-cell responses, which are of high interest for vaccination studies in CIA.
(E)-Alkene and Ethylene Isosteres Substantially Alter the Hydrogen-Bonding Network in Class II MHC Aq/Glycopeptide Complexes and Affect T-Cell Recognition
Ida E. Andersson,Tsvetelina Batsalova,Sabrina Haag,Balik Dzhambazov,Rikard Holmdahl,Jan Kihlberg,Jan Kihlberg,Anna Linusson +7 more
TL;DR: (E)-alkene and ethylene amide-bond isosteres were used to investigate the effect of removing hydrogen-bonding possibilities from the CII259-270 glycopeptide, which is bound by the arthritis-associated murine A(q) class II MHC protein.
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