Ian Tomlinson
University of Birmingham
649 Papers
4.7K Citations
Ian Tomlinson is an academic researcher from University of Birmingham. The author has contributed to research in topics: Cancer & Genome-wide association study. The author has an hindex of 119, co-authored 607 publications. Previous affiliations of Ian Tomlinson include Cancer Research UK & University of Cambridge.
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Papers
Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis
Sebastian May-Wilson,Amit Sud,Philip J. Law,Kimmo Palin,Sari Tuupanen,A. Gylfe,Ulrika A. Hänninen,Tatiana Cajuso,Tomas Tanskanen,Johanna Kondelin,Eevi Kaasinen,Antti-Pekka Sarin,Johan G. Eriksson,Harri Rissanen,Paul Knekt,Eero Pukkala,Pekka Jousilahti,Veikko Salomaa,Samuli Ripatti,Aarno Palotie,Laura Renkonen-Sinisalo,Anna Lepistö,Jan Böhm,Jukka-Pekka Mecklin,Nada Al-Tassan,Claire Palles,Susan M. Farrington,Maria Timofeeva,Brian F. Meyer,S. Wakil,Harry Campbell,Christopher Smith,S. Idziaszczyk,Tim Maughan,David E. Fisher,Rachel Kerr,David Kerr,Michael N. Passarelli,Jane C. Figueiredo,C. D. Buchanan,Aung Ko Win,John L. Hopper,M. Jenkins,Noralane M. Lindor,Polly A. Newcomb,Steven Gallinger,David V. Conti,Fredrick R. Schumacher,Graham Casey,Lauri A. Aaltonen,Jeremy Peter Cheadle,Ian Tomlinson,Malcolm G. Dunlop,Richard S. Houlston +53 more
TL;DR: Results from this analysis are broadly consistent with a pro-inflammatory FA profile having a detrimental effect in terms of CRC risk.
Urgent improvements needed to diagnose and manage Lynch syndrome.
Kevin J. Monahan,Deborah Alsina,Simon P. Bach,James M. Buchanan,John Burn,Susan K. Clark,Peter Dawson,Bianca De Souza,Farhat V N Din,Sunil Dolwani,Malcolm G. Dunlop,James E. East,D. Gareth Evans,Nicola S Fearnhead,Ian M. Frayling,Rob Glynne-Jones,James Hill,Richard S. Houlston,Mark A. Hull,Fiona Lalloo,Andrew Latchford,Suzy Lishman,Phil Quirke,Colin J Rees,Matthew D. Rutter,Peter Sasieni,Asha Senapati,Doug Speake,Huw Thomas,Ian Tomlinson +29 more
TL;DR: The new guideline from the National Institute for Health and Care Excellence recommends universal testing for Lynch syndrome in all people newly diagnosed as having colorectal cancer, which should prevent several hundred colorective cancers annually.
Linkage analysis of candidate regions for coeliac disease genes.
Richard S. Houlston,Ian Tomlinson,D. Ford,Sheila Seal,A Marossy,Anne Ferguson,G. K. T. Holmes,K. B. Hosie,Peter D. Howdle,Derek P. Jewell,Andrew James Godkin,G. D. Kerr,Parveen Kumar,Richard F A Logan,A. H. G. Love,S. Johnston,Michael N. Marsh,S. Mitton,D. O'Donoghue,A. Roberts,J. A. Walker-Smith,M. F. Stratton +21 more
TL;DR: The well established association between coeliac disease and insulin dependent diabetes mellitus, together with the mapping of an IDDM susceptibility locus (IDDM3) to chromosome 15q26, provide indirect support for this as a candidate locus conferring susceptibility to coeliat disease in some families.
Array Comparative Genomic Hybridization Analysis of Colorectal Cancer Cell Lines and Primary Carcinomas
Eleanor J. Douglas,Heike Fiegler,Andrew Rowan,Sarah Halford,David C. Bicknell,Walter F. Bodmer,Ian Tomlinson,Nigel P. Carter +7 more
TL;DR: The overall pattern of copy number change was strikingly similar between cell lines and primary cancers with a few obvious exceptions such as loss of chromosome 6 and gain of chromosomes 15 and 12p in the former.
Targeted next generation sequencing reveals a common genetic pathway for colorectal cancers with chromosomal instability and those with microsatellite and chromosome stability.
Hersh A. Ham-Karim,Henry O Ebili,Kirsty Bradshaw,Susan D. Richman,Wakkas Fadhil,Enric Domingo,Ian Tomlinson,Mohammad Ilyas +7 more
TL;DR: The mutation profiles of CIN and MACS CRCs are similar and the events allowing aneuploidy (or forcing retention of diploidsy) remain unknown.