10 Papers
57 Citations
Ian Rowe is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: Mechanosensitive channels & Osmolyte. The author has an hindex of 5, co-authored 10 publications.
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Papers
Activation of bacterial channel MscL in mechanically stimulated droplet interface bilayers
Joseph S. Najem,Myles D. Dunlap,Ian Rowe,Eric C. Freeman,John W. Grant,Sergei Sukharev,Donald J. Leo +6 more
TL;DR: The first reconstitution and activation of the low-threshold V23T mutant of MscL in a DIB as a response to axial compressions of the droplets is reported, clarifying the principles of interconversion between bulk and surface forces in the DIB, and facilitates the measurements of fundamental membrane properties.
52
Membrane Affinity of Platensimycin and Its Dialkylamine Analogs
TL;DR: It is concluded that the biological activity among the studied PL analogs is unlikely to be limited by their membrane permeability, and the capacity of endogenous tension-activated channels to detect asymmetric partitioning of exogenous substances into the native bacterial membrane is discussed.
6
The Hollow Domain of the Mechanosensitive Channel MscS is a Sensor of Cytoplasmic Crowding
TL;DR: The cage is the first example of a hollow channel domain that can provide feedback on the degree of cytoplasm condensation (crowding) that disengages the gate and prevents efflux of osmolytes and is concluded that the shape changes make the cage an intracellular crowding sensor which functions through labile kink-stabilizing TM3-beta interactions.
2
The Tension-Activated Channels in the Cytoplasmic Membrane of Vibrio Cholerae
TL;DR: Tension-activated channels which act as osmolyte release valves in the cytoplasmic membrane of Vibrio cholerae can be used as lateral pressure gauges to detect partitioning of lipophilic signaling molecules.
1
Tension-activated channels in the mechanism of osmotic fitness in Pseudomonas aeruginosa
Ugur Cetiner,Ian Rowe,Anthony Schams,Christina Mayhew,Deanna Rubin,Andriy Anishkin,Sergei Sukharev +6 more
TL;DR: It is concluded that PA relies on MscL as the major valve defining a high rate of osmolyte release sufficient to curb osmotic swelling under extreme shocks, but it still requires MscS-type channels with a strong propensity to inactivation to properly terminate massive permeability response.