Ian Robert Baldwin
GlaxoSmithKline
28 Papers
295 Citations
Ian Robert Baldwin is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Chemistry & Derivative (chemistry). The author has an hindex of 11, co-authored 28 publications.
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Papers
Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease
Kenneth David Down,Augustin Amour,Ian Robert Baldwin,Anthony William James Cooper,Angela M. Deakin,Leigh M. Felton,Stephen Barry Guntrip,Charlotte J. Hardy,Zoe Alicia Harrison,Katherine Louise Jones,Paul Jones,Suzanne Elaine Keeling,Joelle Le,Stefano Livia,Fiona S. Lucas,Christopher James Lunniss,Nigel J. Parr,Ed Robinson,Paul Rowland,Sarah Smith,Daniel Thomas,Giovanni Vitulli,Yoshiaki Washio,J. Nicole Hamblin +23 more
TL;DR: Optimization of lead compound 1, through extensive use of structure-based design and a focus on PI3Kδ potency, isoform selectivity, and inhaled PK properties, led to the discovery of clinical candidates 2 and 3 for the treatment of respiratory indications via inhalation.
138
Patent
Fused heteroaryl derivatives for use as p38 kinase inhibitors in the treatment of i.a. rheumatoid arthritis
Richard Martyn Arrow Therapeutics Ltd Angell,Ian Robert Baldwin,Paul Bamborough,Nigel Marc Deboeck,Timothy Longstaff,Stephen Swanson +5 more
- 30 Jul 2003
TL;DR: In this paper, a 5-membered heteroaryl ring is used as an inhibitor of p38 kinase and is useful in the treatment of conditions or disease states mediated by p38 activity or mediated by cytokines produced by the activity of P38.
79
Patent
Fused pyrazole derivatives being protein kinase inhibitors
Michael John GlaxoSmithKline Alberti,Ian Robert Baldwin,Mui GlaxoSmithKline Cheung,Stuart G. Cockerill,Stephen Sean Flack,Philip Anthony Harris,David Kendall Jung,Gregory GlaxoSmithKline Peckham,Michael Robert Peel,Jennifer Badiang Stanford,Kirk GlaxoSmithKline Stevens,James Marvin Veal +11 more
- 22 Aug 2001
TL;DR: Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R?1, R2 and R4? are various substituent groups, are protein kinase inhibitors as discussed by the authors.
61
Patent
Benzpyrazole derivatives as inhibitors of p13 kinases
Ian Robert Baldwin,Kenneth David Down,Paul Faulder,Simon Gaines,Julie Nicole Hamblin,Katherine Louise Jones,Paul Spencer Jones,Joelle Le,Christopher James Lunniss,Nigel James Parr,Timothy John Ritchie,John Edward Robinson,Juliet Kay Simpson,Christian Alan Paul Smethurst +13 more
- 03 Dec 2010
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Kinase array design, back to front: Biaryl amides
Ian Robert Baldwin,Paul Bamborough,Claudine Haslam,Suchete S. Hunjan,Tim Longstaff,Christopher J. Mooney,Shila Patel,Jo Quinn,Don O. Somers +8 more
TL;DR: An alternative pharmacophore-guided array approach is described which set out to discover novel purine subpocket-binding groups for p38alpha and cFMS kinase, for which multiple distinct series with nanomolar potency were discovered.
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