Ian Perrone
National Institutes of Health
4 Papers
1 Citations
Ian Perrone is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Globin. The author has an hindex of 2, co-authored 3 publications.
Chat about Author
Papers
•Journal Article
MAdCAM signaling through integrin α4β7 modulates surface expression of CCR5 and markers of CD4+ T cell activation.
Ian Perrone,Claudia Cicala,Fatima Nawaz,Jocelyn C Ray,Ronke Olowojesiku,Mia Waliszewski,Katija Jelicic,Danlan Wei,Donald Van Ryk,Aftab A. Ansari,Anthony S. Fauci,James Arthos +11 more
TL;DR: The response of α 4 β 7 + /CD4 + T cells to costimulation via MAdCAM is characterized to better understand whether the induced phenotype would support an enhanced degree of viral replication.
1
Single-Cell RNA Sequencing of Sickle Cell Reticulocytes to Identify Beta-Globin Genotypes and Associated Gene Expression Differences
Sebastian Treusch,Twaritha Vijay,William M. Matern,Kristina Krassovsky,Vincent Siu,Ian Perrone,Glen M. Chew,Jane Grogan,Alana G. Lerner +8 more
TL;DR: In this article , a single-cell RNA sequencing (scRNAseq) method was developed to enable enumeration of potential gene-editing outcomes in peripheral reticulocytes.
MAdCAM costimulation through Integrin-α4β7 promotes HIV replication.
Fatima Nawaz,Livia R. Goes,Jocelyn C Ray,Ronke Olowojesiku,Alia Sajani,Aftab A. Ansari,Ian Perrone,Joseph Hiatt,Donald Van Ryk,Danlan Wei,Mia Waliszewski,Marcelo A. Soares,Katija Jelicic,Mark Connors,Stephen A. Migueles,Elena Martinelli,Francois Villinger,Claudia Cicala,Anthony S. Fauci,James Arthos +19 more
TL;DR: It is reported here that MAdCAM delivers a potent costimulatory signal to naive and memory CD4+ T cells following ligation with α4β7, which promotes high levels of HIV replication and highlights the potential of such agents to control acute HIV infection.
The V2 loop of HIV gp120 delivers costimulatory signals to CD4 + T cells through Integrin α 4 β 7 and promotes cellular activation and infection
Livia R. Goes,Alia Sajani,Aida Sivro,Ronke Olowojesiku,Jocelyn C Ray,Ian Perrone,Jason Yolitz,Alexandre Girard,Louise Leyre,Constantinos Kurt Wibmer,Lynn Morris,Giacomo Gorini,Genoveffa Franchini,Rosemarie D. Mason,Mario Roederer,Saurabh Mehandru,Marcelo A. Soares,Claudia Cicala,Anthony S. Fauci,James Arthos +19 more
TL;DR: It is reported that gp120 V2 shares with MAdCAM the capacity to signal through α4β7 resulting in CD4+ T cell activation and proliferation and the capacity of nonneutralizing V2 antibodies to block this activity reveals a previously unrecognized mechanism whereby such antibodies might impact HIV transmission and pathogenesis.