Ian G. Macara
Vanderbilt University
166 Papers
2.3K Citations
Ian G. Macara is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Cell polarity & Ran. The author has an hindex of 77, co-authored 161 publications. Previous affiliations of Ian G. Macara include University of Vermont & University of Virginia.
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Papers
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
TL;DR: It is demonstrated that human pre-miRNA nuclear export, and miRNA function, are dependent on Exportin-5, an additional cellular cofactor required for miRNA biogenesis and function.
Transport into and out of the Nucleus
TL;DR: This review focuses on recent discoveries in the field, with an emphasis on the carriers and cofactors involved in transport and on possible mechanisms for movement through the nuclear pores.
966
Organization and execution of the epithelial polarity programme
TL;DR: Insight is provided into the interactions of the EPP with the polarized trafficking machinery and how these regulate epithelial polarization and depolarization.
682
Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex
Enrico Brugnera,Lisa B. Haney,Cynthia Grimsley,Mingjian Lu,Scott F. Walk,Annie-Carole Tosello-Trampont,Ian G. Macara,Hiten D. Madhani,Gerald R. Fink,Kodimangalam S. Ravichandran +9 more
TL;DR: A domain within Dock180 is identified that specifically recognizes nucleotide-free Rac and can mediate GTP loading of Rac in vitro and it is proposed that the Dock180–ELMO complex functions as an unconventional two-part exchange factor for Rac.
627
Direct interaction of two polarity complexes implicated in epithelial tight junction assembly.
TL;DR: The identification of a biochemical and functional link between these two complexes that is mediated by Par6 and PALS1 is highlighted, highlighting a previously unrecognized link between protein complexes that are essential for epithelial polarity and formation of tight junctions.
517