Ian E. James

TL;DR: The abundant expression of cathepsin K selectively in osteoclasts strongly suggests that it plays a specialized role in bone resorption and suggests that random sequencing of ESTs from cDNA libraries is a valuable approach for identifying novel cell-selective genes.

TL;DR: It is demonstrated that an increase in endogenous PTH secretion, induced by antagonism of the parathyroid cell Ca(2+) receptor with a small molecule, leads to a dramatic increase in bone turnover, and it is suggested that a novel approach to the treatment of osteoporosis is suggested.

TL;DR: Inhibitors of cathepsin K are effective at reducing osteoclast‐mediated bone resorption and may have therapeutic potential in diseases of excessive bone Resorption such as rheumatoid arthritis or osteoporosis.

TL;DR: This study characterized expression of osteopontin mRNA and protein expression in both intramembranous and endochondral ossification, as well as remodeling bone, in the human osteophyte and confirmed that osteoclasts are responsible for the deposition of osteOPontin in vitro.