Iain Simpson
AstraZeneca
21 Papers
157 Citations
Iain Simpson is an academic researcher from AstraZeneca. The author has contributed to research in topics: Catalysis & Aryl. The author has an hindex of 8, co-authored 21 publications. Previous affiliations of Iain Simpson include Micron Technology.
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Papers
In Vitro Activities of Novel Oxapenems, Alone and in Combination with Ceftazidime, against Gram-Positive and Gram-Negative Organisms
TL;DR: The oxapenems markedly reduced the MICs for ceftazidime against class C hyperproducing strains and strains producing TEM- and SHV-derived ESBLs and failed to enhance the activity of ceFTazidimes against derepressed AmpC-producing Pseudomonas aeruginosa strains.
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Amidation of Esters with Amino Alcohols Using Organobase Catalysis
Nicola Caldwell,Peter S. Campbell,Craig Jamieson,Frances Potjewyd,Iain Simpson,Allan J. B. Watson +5 more
TL;DR: Investigations into mechanistic aspects of the process indicate that the reaction involves an initial transesterification, followed by an intramolecular rearrangement.
Isolation from clinical sources of Burkholderia cepacia possessing characteristics of Burkholderia gladioli.
TL;DR: Further characterization of 32 clinical isolates originally identified as Burkholderia cepacia by biochemical and fatty acid profiling revealed the presence of 12 strains bearing partial resemblance to the closely related species Burk holderia gladioli, which reinforces the previous opinion that hybrids between B. cEPacia and B. gladiolo exist and may possess a significant pathogenic role.
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In vitro and in vivo activities of AM-112, a novel oxapenem
TL;DR: AM-112 was effective at protecting ceftazidime against extended-spectrum β-lactamase-producing strains and derepressed class C enzyme producers, reducing ceftrazidime MICs by 16- and 2,048-fold.
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De novo synthesis of multisubstituted aryl amines using alkene cross metathesis.
TL;DR: This de novo arene synthesis yields nonclassical substitution patterns in a regioselective and predictable approach that is compatible with several functional groups.
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