Recent developments in dynamic kinetic resolution

In this study, a miniature stirred tank bioreactor was designed for treatment of waste gas containing benzene, toluene and xylene. Oxygen mass transfer characteristics for various twin and single-impeller systems were investigated for 6 configurations in a vessel with 10 cm of inner diameter and working volume of 1.77L. Three types of impellers, namely, Rushton turbine, Pitched 4blades and Pitched 2blades impellers with downward pumping have been used. Deionized water was used as a liquid phase. With respect to other independent variables such as agitation speed, aeration rate, type of sparger, number of impellers, the relative performance of these impellers was assessed by comparing the values of (KLa) as a key parameter. Based on the experimental data, empirical correlations as a function of the operational conditions have been proposed, to study the oxygen transfer rates from air bubbles generated in the bioreactor. It was shown that twin Rushton turbine configuration demonstrates superior performance (23% to 77% enhancement in KLa) compared with other impeller compositions and that sparger type has negligible effect on oxygen mass transfer rate. Agitation speeds of 400 to 800 rpm were the most efficient speeds for oxygen mass transfer in the stirred bioreactor.

/pdf/oxygen-mass-transfer-in-a-stirred-tank-bioreactor-using-4ol65iyaen.pdf

Oxygen mass transfer in a stirred tank bioreactor using different impeller configurations for environmental purposes

Chemoenzymatic and microbial dynamic kinetic resolutions.

Metal-free enantiocomplementary hydrolytic dynamic kinetic resolution of Morita–Baylis–Hillman (MBH) acetates was developed using triethylamine (TEA) as a racemization catalyst and wild-type or engineered lipase B from Candida antarctica (CALB) as stereoselectivity-determining catalyst, leading to chiral MBH alcohols with tailor-made R or S configurations on an optional basis In the TEA-WT CALB catalysis system, WT CALB displays excellent S enantioselectivity for a series of MBH acetates tested (up to 96% ee and 98% conversion) Reversal of enantioselectivity in favor of (R)-MBH alcohols (95% ee; 95% conversion) was achieved by generating a focused site-specific mutagenesis library composed of less than 20 variants Molecular modeling explains the origin of stereoselectivity

Stereoselectivity-Tailored, Metal-Free Hydrolytic Dynamic Kinetic Resolution of Morita–Baylis–Hillman Acetates Using an Engineered Lipase–Organic Base Cocatalyst

Lipase-catalyzed dynamic kinetic resolution of racemic ibuprofen ester via hollow fiber membrane reactor: Modeling and simulation

The hydrolytic resolution of (R,S)-2,2,2-trifluoroethyl α-chlorophenylacetate in water-saturated isooctane containing Lipase MY(I) at 35 °C is selected as the best reaction condition for producing (R)-α-chlorophenyl acetic acid. The kinetic constants, and hence an enantiomeric ratio of 33.6, are estimated and employed for the modeling of time-course conversions of both substrates by considering product inhibition and enzyme deactivation effects. A successful dynamic kinetic resolution is also achieved, giving the desired (R)-α-chlorophenylacetic acid of 93.0% yield and eeP = 89.5% when 80 mmol dm−3 trioctylamine acting as the racemization catalyst and enzyme activator is initially added. Copyright © 2006 Society of Chemical Industry

Lipase-catalyzed dynamic hydrolytic resolution of (R,S)-2,2,2-trifluoroethyl α-chlorophenyl acetate in water-saturated isooctane

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Lipase-catalyzed dynamic hydrolytic resolution of (R,S)-2,2,2-trifluoroethyl α-chlorophenyl acetate in water-saturated isooctane