Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region.

/pdf/neuronal-circuitry-for-pain-processing-in-the-dorsal-horn-3qcz3saaaq.pdf

Neuronal circuitry for pain processing in the dorsal horn

The cellular and synaptic architecture of the mechanosensory dorsal horn

https://www.zora.uzh.ch/id/eprint/109985/1/Foster_Zeilhofer_Neuron%282015%29.pdf

Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch

https://www.cell.com/cell-reports/pdf/S2211-1247(15)01134-1.pdf

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury

The types of neuron which contain protein kinase C gamma in rat spinal cord.

Subpopulations of GABAergic neurons in laminae I-III of rat spinal dorsal horn defined by coexistence with classical transmitters, peptides, nitric oxide synthase or parvalbumin.

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Subpopulations of GABAergic neurons in laminae I-III of rat spinal dorsal horn defined by coexistence with classical transmitters, peptides, nitric oxide synthase or parvalbumin.