I-Hsiu Lee
Harvard University
11 Papers
I-Hsiu Lee is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 3 publications.
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Papers
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity.
Ellen Shrock,Ellen Shrock,Eric Fujimura,Eric Fujimura,Tomasz Kula,Tomasz Kula,Richard T. Timms,Richard T. Timms,I-Hsiu Lee,Yumei Leng,Yumei Leng,Matthew L Robinson,Brandon M. Sie,Brandon M. Sie,Mamie Z. Li,Mamie Z. Li,Yuezhou Chen,Jennifer K. Logue,Adam Zuiani,Denise J. McCulloch,Felipe J.N. Lelis,Stephanie A. Henson,Daniel R. Monaco,Meghan Travers,Shaghayegh Habibi,William Clarke,Patrizio Caturegli,Oliver Laeyendecker,Oliver Laeyendecker,Alicja Piechocka-Trocha,Jonathan Z. Li,Ashok Khatri,Helen Y. Chu,Alexandra-Chloé Villani,Kyle R. Kays,Marcia B. Goldberg,Nir Hacohen,Michael R. Filbin,Xu G. Yu,Bruce D. Walker,Bruce D. Walker,Duane R. Wesemann,H. Benjamin Larman,James A. Lederer,Stephen J. Elledge,Stephen J. Elledge +45 more
TL;DR: A systematic characterization of the humoral response to severe acute respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed, important for understanding the immunogenicity of the viral proteome and the basis for cross-reactivity with the common-cold coronaviruses.
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Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9.
Dong Niu,Hong-Jiang Wei,Lin Lin,Haydy George,Tao Wang,I-Hsiu Lee,Hong-Ye Zhao,Yong Wang,Yinan Kan,Ellen Shrock,Emal Lesha,Gang Wang,Yonglun Luo,Yubo Qing,Deling Jiao,Heng Zhao,Xiaoyang Zhou,Shouqi Wang,Hong Wei,Marc Güell,George M. Church,George M. Church,Luhan Yang +22 more
TL;DR: The value ofPERV inactivation to prevent cross-species viral transmission is highlighted and the successful production of PERV-inactivated animals to address the safety concern in clinical xenotransplantation are demonstrated.
Recruited macrophages elicit atrial fibrillation
Maarten Hulsmans,Maximilian J. Schloss,I-Hsiu Lee,Aneesh Bapat,Yoshiko Iwamoto,C. Vinegoni,Alexandre Paccalet,Masahiro Yamazoe,Jana Grune,Steffen Pabel,Noor Momin,Han Hwa Seung,Fadi E. Pulous,C. Bening,Ursula Green,Jochen K. Lennerz,Richard N. Mitchell,Andrew J.M. Lewis,Barbara Casadei,Oriol Iborra-Egea,Antoni Bayes-Genis,Samuel Sossalla,Chin Siang Ong,Richard N. Pierson,Jon C. Aster,David Rohde,Gregory R. Wojtkiewicz,Ralph Weissleder,Filip K. Swirski,George Tellides,George Tolis,Serguei Melnitchouk,David J. Milan,Patrick T. Ellinor,Kamila Naxerova,Matthias Nahrendorf +35 more
TL;DR: Hulsmans et al. as mentioned in this paper deciphered how immune and stromal cells contribute to atrial fibrillation, and identified SPP1+ macrophages as targets for immunotherapy.
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B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis
Maximilian J. Schloss,Maarten Hulsmans,David Rohde,I-Hsiu Lee,Nicolas Severe,Brody H. Foy,Fadi E. Pulous,Shuang Zhang,Konstantinos D. Kokkaliaris,Vanessa Frodermann,Gabriel Courties,Chongbo Yang,Yoshiko Iwamoto,Anders S. Knudsen,Cameron S. McAlpine,Masahiro Yamazoe,Stephen D. Schmidt,Gregory R. Wojtkiewicz,Gustavo S. Masson,Karin Gustafsson,Diane E. Capen,Dennis Brown,John M. Higgins,David T. Scadden,Peter Libby,Filip K. Swirski,Kamila Naxerova,Matthias Nahrendorf +27 more
TL;DR: Nahrendorf et al. as discussed by the authors showed that B lymphocytes are an important source of acetylcholine, a neurotransmitter of the parasympathetic nervous system, which reduced hematopoiesis.
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Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses
Ellen Shrock,Richard T. Timms,Tomasz Kula,Elijah L. Mena,Anthony P. West,Rui Guo,I-Hsiu Lee,Alexander A. Cohen,Lindsay McKay,Caihong Bi,Keerti,Yumei Leng,Eric Fujimura,Felix Horns,Mamie Z. Li,Duane R. Wesemann,Anthony Griffiths,Benjamin E. Gewurz,Pamela J. Bjorkman,Stephen J Elledge +19 more
TL;DR: Shrock et al. as discussed by the authors used a phage display platform called VirScan to identify the epitopes of antiviral antibodies from a large cohort of individuals in a high-throughput manner.
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