Hyewon Shin
KAIST
19 Papers
12 Citations
Hyewon Shin is an academic researcher from KAIST. The author has contributed to research in topics: PDZ domain & Postsynaptic density. The author has an hindex of 14, co-authored 19 publications.
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Papers
The GIT Family of Proteins Forms Multimers and Associates with the Presynaptic Cytomatrix Protein Piccolo
Seho Kim,Jaewon Ko,Hyewon Shin,Jae-Ran Lee,Chunghun Lim,Jin-Hee Han,Wilko D. Altrock,Craig C. Garner,Eckart D. Gundelfinger,Richard T. Premont,Bong-Kiun Kaang,Eunjoon Kim +11 more
TL;DR: A novel interaction between Piccolo, a core component of the CAZ, and GIT proteins, multidomain signaling integrators with GTPase-activating protein activity for ADP-ribosylation factor small GTPases is reported, suggesting that the GIT family proteins are involved in the organization of theCAZ.
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Association of the kinesin superfamily motor protein KIF1Bα with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins
TL;DR: The results suggest that the PSD-95 family proteins and S-SCAM have a novel function as KIF1Bα receptors, linking KIF 1Bα to its specific cargos, and are involved in peripheral neuropathies.
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Effects of cenobamate (YKP3089), a newly developed anti-epileptic drug, on voltage-gated sodium channels in rat hippocampal CA3 neurons
TL;DR: Cenobamate significantly shifted the steady-state fast inactivation relationship toward a hyperpolarizing range, indicating that cenobamine binds to voltage-gated Na+ channels at the inactivated state with a higher affinity.
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Positive allosteric modulation of GABAA receptors by a novel antiepileptic drug cenobamate
Ramesh Sharma,Michiko Nakamura,Chiranjivi Neupane,Byeong Hwa Jeon,Hyewon Shin,Susan M. Melnick,Kelli J. Glenn,Il-Sung Jang,Jin Bong Park +8 more
TL;DR: Results showed that cenobamate acts as a positive allosteric modulator of high-affinity GABAA receptors, activated by GABA at a site independent of the benzodiazepine binding site and efficiently enhances Itonic inhibition in hippocampal neurons, which could be an underlying molecular mechanism stabilizing neural circuits of the epileptic hippocampus.
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Inhibitory Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Anion-transporting Activities by Shank2
Joo Young Kim,Won Sun Han,Wan Namkung,Ji Hyun Lee,Kyung Hwan Kim,Hyewon Shin,Eunjoon Kim,Min Goo Lee +7 more
TL;DR: The results indicate that Shank2 negatively regulates CFTR and that this may play a significant role in maintaining epithelial homeostasis under normal and diseased conditions such as those presented by secretory diarrhea.
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