Hye-Sun Kim

TL;DR: It is demonstrated that minocycline has neuroprotective effects in in vitro and in vivo Alzheimer's disease models, and may prove to be a good candidate as an effective therapeutic agent for Alzheimer’s disease.

TL;DR: It is demonstrated for the first time that the C‐terminal fragments of APP exert neurotoxicity on differentiated PC 12 cells and rat primary cortical neurons by inducing the expression of glycogen synthase kinase 3β, forming a ternary complex with Fe65 and CP2/LSF/LBP1 in the nucleus.

TL;DR: It is shown that α‐SN plays dual roles of neuroprotection and neurotoxicity depending on its concentration or level of expression, and at nanomolar concentrations, α‐ SN protected neurons against serum deprivation, oxidative stress, and excitotoxicity through the PI3/Akt signaling pathway.

TL;DR: It is shown that the phosphorylation of the APP intracellular domain (AICD) at T668 is essential for its binding to Fe65 and its nuclear translocation and affects the resultant neurotoxicity, possibly mediated through the induction of glycogen synthase kinase 3β and tauosphorylation by enhancing the formation of a ternary complex with Fe65and CP2 transcription factor.