Hye Ra Lee
University of Southern California
5 Papers
13 Citations
Hye Ra Lee is an academic researcher from University of Southern California. The author has contributed to research in topics: Lytic cycle & Biology. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Hye Ra Lee include Harvard University.
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Papers
Construction and Manipulation of a New Kaposi's Sarcoma-Associated Herpesvirus Bacterial Artificial Chromosome Clone
Kevin Brulois,Heesoon Chang,Heesoon Chang,Amy S. Lee,Armin Ensser,Lai Yee Wong,Lai Yee Wong,Zsolt Toth,Sun Hwa Lee,Hye Ra Lee,Hye Ra Lee,Jinjong Myoung,Don Ganem,Tae Kwang Oh,Jihyun F. Kim,Shou-Jiang Gao,Jae U. Jung,Jae U. Jung +17 more
TL;DR: The data presented here demonstrate the utility of BAC16 for the generation and characterization of KSHV knockout and mutant recombinants and further emphasize the importance of functional analysis of viral genes in the context of the KSHv genome besides the study of individual gene expression.
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G1-S Cell Cycle Progression via Deregulation of the cyclin D1 Gene.
Hye Ra Lee,Jaba Mitra,Stacy Lee,Shou-Jiang Gao,Tae Kwang Oh,Myung Hee Kim,Taekjip Ha,Jae U. Jung +7 more
TL;DR: KSHV vIRF4 targets the β-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter, suppressing the G1-S cell cycle progression and enhancing KSHV replication.
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Biphasic Euchromatin-to-Heterochromatin Transition on the KSHV Genome Following De Novo Infection
Zsolt Toth,Kevin Brulois,Hye Ra Lee,Yoshihiro Izumiya,Clifford G. Tepper,Hsing Jien Kung,Jae U. Jung +6 more
TL;DR: The data demonstrate that the KSHV genome undergoes a temporally-ordered biphasic euchromatin-to-heterochromatin transition in endothelial cells, leading to latent infection, whereas K SHV preferentially adopts a transcriptionally active euchROMatin in oral epithelial cells; resulting in lytic gene expression.
Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance.
Un Yung Choi,Jae Jin Lee,Angela Park,Kyle L. Jung,Shin-Ae Lee,Youn Jung Choi,Hye Ra Lee,Chih-Jen Lai,Hyungjin Eoh,Jae U. Jung +9 more
TL;DR: In this paper , Kaposi's sarcoma-associated herpesvirus (KSHV) upregulates intracellular spermidine levels by dysregulating polyamine metabolic pathways in three-dimensional (3D) culture and 2D de novo infection conditions.
Inhibition of retromer activity by Herpesvirus saimiri Tip leads to CD4 downregulation and efficient T cell transformation
Dior Kingston,Heesoon Chang,Heesoon Chang,Armin Ensser,Hye Ra Lee,Hye Ra Lee,Jong-Soo Lee,Jong-Soo Lee,Sun Hwa Lee,Jae U. Jung,Jae U. Jung,Nam Hyuk Cho,Nam Hyuk Cho +12 more
TL;DR: The herpesvirus saimiri tyrosine kinase-interacting protein (Tip), required for the immortalization of primary T lymphocytes, uniquely targets the retromer complex to impair the intracellular trafficking functions of infected cells, ultimately contributing to efficient T cell transformation.