Hunter Bennett
University of California, San Diego
8 Papers
1 Citations
Hunter Bennett is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Kupffer cell & Macrophage. The author has an hindex of 2, co-authored 5 publications.
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Papers
Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.
Jason S. Seidman,Ty D. Troutman,Mashito Sakai,Anita Gola,Nathanael J. Spann,Hunter Bennett,Cassi M. Bruni,Zhengyu Ouyang,Rick Z. Li,Xiaoli Sun,Bao Chau T. Vu,Martina P. Pasillas,Kaori M. Ego,David Gosselin,Verena M. Link,Ling Wa Chong,Ronald M. Evans,Bonne M. Thompson,Jeffrey G. McDonald,Mojgan Hosseini,Joseph L. Witztum,Ronald N. Germain,Christopher K. Glass +22 more
TL;DR: Findings reveal mechanisms by which disease-associated environmental signals instruct resident and recruited macrophages to acquire distinct gene expression programs and corresponding functions.
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Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity.
Mashito Sakai,Ty D. Troutman,Jason S. Seidman,Zhengyu Ouyang,Nathanael J. Spann,Yohei Abe,Kaori M. Ego,Cassi M. Bruni,Zihou Deng,Johannes C. M. Schlachetzki,Alexi Nott,Hunter Bennett,Jonathan Chang,Bao Chau T. Vu,Martina P. Pasillas,Verena M. Link,Verena M. Link,Lorane Texari,Sven Heinz,Bonne M. Thompson,Jeffrey G. McDonald,Frederic Geissmann,Christopher K. Glass +22 more
TL;DR: Analysis of transcriptomic and epigenetic changes in repopulating liver macrophages following acute Kupffer cell depletion provides a framework for understanding how macrophage progenitor cells acquire tissue-specific phenotypes.
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Epigenetic Regulation of Kupffer Cell Function in Health and Disease
TL;DR: In this article, a model by which liver-environment specific signals induce lineage determining transcription factors (LDTFs) necessary for differentiation of Kupffer cells from bone-marrow derived monocytes is presented.
Human microglia maturation is underpinned by specific gene regulatory networks.
Claudia Z. Han,Rick Z. Li,E. Hansen,Samantha Trescott,Bethany Fixsen,C. Nguyen,Cristina M. Mora,Nathanael J. Spann,Hunter Bennett,Olivier Poirion,Justin Buchanan,Anna S. Warden,Bing Xia,Johannes C. M. Schlachetzki,Martina P. Pasillas,Sebastian Preissl,Allen Wang,Carolyn O’Connor,S. Shriram,Roy J. Kim,Danielle Schafer,G. Ramírez,Jean Challacombe,Samuel A. Anavim,Avalon Johnson,Mihir Gupta,I. A. Glass,Michael Levy,Sharona Ben Haim,David D. Gonda,Louise C. Laurent,Jennifer F. Hughes,David C. Page,Mathew Blurton-Jones,Christopher K. Glass,Nicole G. Coufal +35 more
TL;DR: Stage-specific transcriptomes and epigenetic landscapes of fetal and postnatal human microglia are characterized and corresponding data is acquired in induced pluripotent stem cell (iPSC)-derivedmicroglia, in cerebral organoids, and following engraftment into humanized mice.
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Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes.
Hunter Bennett,Ty D. Troutman,Enchen Zhou,Nathanael J. Spann,Verena M. Link,Jason S. Seidman,Christian K Nickl,Yohei Abe,Mashito Sakai,Martina P. Pasillas,Justin M. Marlman,Carlos Guzman,Mojgan Hosseini,Bernd Schnabl,Christopher K Glass +14 more
TL;DR: Investigation of effects of natural genetic variation on the epigenomes and transcriptomes of Kupffer cells derived from inbred mouse strains identified strain-specific environmental factors influencing K upffer cell phenotypes, including leptin signaling in KUpffer cells from a steatohepatitis-resistant strain.
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