Hung Lamthanh
Centre national de la recherche scientifique
21 Papers
378 Citations
Hung Lamthanh is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Peptide & Conotoxin. The author has an hindex of 9, co-authored 21 publications.
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Papers
Three-dimensional structure of kappa-conotoxin PVIIA, a novel potassium channel-blocking toxin from cone snails.
Philippe Savarin,Marc Guenneugues,Bernard Gilquin,Hung Lamthanh,Sylvaine Gasparini,Sophie Zinn-Justin,André Ménez +6 more
TL;DR: It is shown that kappa-conotoxin competes with radioactive alpha-dendrotoxin for binding to rat brain synaptosomes, confirming its capacity to bind to potassium channels; however, it behaves as a weak competitor.
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A δ-Conotoxin from Conus ermineus Venom Inhibits Inactivation in Vertebrate Neuronal Na+ Channels but Not in Skeletal and Cardiac Muscles
Julien Barbier,Hung Lamthanh,Frédéric Le Gall,Philippe Favreau,Evelyne Benoit,Haijun Chen,Nicolas Gilles,Nitza Ilan,Stefan H. Heinemann,Dalia Gordon,André Ménez,Jordi Molgó +11 more
TL;DR: In this paper, the authors have isolated δ-conotoxin EVIA (δ-EVIA), a conopeptide in Conus ermineus venom that contains 32 amino acid residues and a six-cysteine/four-loop framework similar to that of previously described ω-, δ-, μO-, and κ -conotoxins.
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Minimal conformation of the alpha-conotoxin ImI for the alpha7 neuronal nicotinic acetylcholine receptor recognition: correlated CD, NMR and binding studies.
TL;DR: The alpha-ImI conotoxin, a selective potent inhibitor of the mammalian neuronal alpha7 nicotinic acetylcholine receptor (n-AchR), was shown by point mutation or by L-alanine scanning to display two regions essential for bioactivity: the active site Asp5-Pro6-Arg7 in the first loop and Trp10 in the second loop.
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NMR solution structures of delta-conotoxin EVIA from Conus ermineus that selectively acts on vertebrate neuronal Na+ channels.
Laurent Volpon,Hung Lamthanh,Julien Barbier,Nicolas Gilles,Jordi Molgó,André Ménez,Jean-Marc Lancelin +6 more
TL;DR: P13A δ-conotoxin EVIA was estimated only two times less active than the wild-type EVIA in binding competition to rat brain synaptosomes and when injected intracerebroventricularly into mice.
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Side reaction during the deprotection of (S-acetamidomethyl)cysteine in a peptide with a high serine and threonine content.
TL;DR: The efficiency of a trivalent alcohol, glycerol, as scavenger in the both Tl(TFA)3 and mercuric/ferricyanide methods, in an attempt to circumvent this side-reaction during the disulfide bond formation step starting from a bis-Cys(Acm) peptide with a high Ser and Thr content, such as the N-terminal loop of neurotoxin, model peptide II or a similar peptide.
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