4 Papers
70 Citations
Humera Khan is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Proto-oncogene tyrosine-protein kinase Src & CD28. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Humera Khan include University of Texas at Austin.
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Papers
•Journal Article
Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.
Tatsuro Furui,Ruth LaPushin,Muling Mao,Humera Khan,Steve R. Watt,Mary Ann V. Watt,Yiling Lu,Xianjun Fang,Shinichi Tsutsui,Zahid H. Siddik,Robert C. Bast,Gordon B. Mills +11 more
TL;DR: Observations suggest that Edg-2 may be a negative regulator for ovarian epithelial cell growth and metastasis.
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•Journal Article
Phosphatidylinositol 3-Kinase Is Required for CD28 But Not CD3 Regulation of the TEC Family Tyrosine Kinase EMT/ITK/TSK: Functional and Physical Interaction of EMT with Phosphatidylinositol 3-Kinase
Yiling Lu,Bruce Cuevas,Spencer Gibson,Spencer Gibson,Humera Khan,Ruth LaPushin,John B. Imboden,Gordon B. Mills +7 more
TL;DR: It is reported that inhibition of PI3K activity with the specific inhibitors LY294002 and wortmannin markedly decreased EMT activation induced by CD28 cross-linking but not by CD3 cross- linking, suggesting that EMT is differentially regulated and recruited to different signaling complexes following ligation of CD28 or the TCR complex.
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Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK.
Spencer Gibson,Kenneth E. Truitt,Yiling Lu,Ruth LaPushin,Humera Khan,John B. Imboden,Gordon B. Mills +6 more
TL;DR: The data indicate that the distal three tyrosines in CD28 are integral to the activation of LCK and EMT/ITK and for subsequent IL2 production.
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells
Yiling Lu,Yue Zhen Lin,Ruth LaPushin,Bruce D. Cuevas,Xianjun Fang,Shuang Xing Yu,Michael A. Davies,Humera Khan,Tatsuro Furui,Muling Mao,Ralph Zinner,Mien Chie Hung,Peter A. Steck,Kathy Siminovitch,Gordon B. Mills +14 more
TL;DR: It is demonstrated that PTEN effects on the PI3K signaling cascade are influenced by the cell stimulatory context, and that depending on the exposure to growth factors and other exogenous stimuli, PTEN can induce cell cycle arrest, apoptosis or anoikis in breast cancer cells.