Human Rezaei
Institut national de la recherche agronomique
57 Papers
299 Citations
Human Rezaei is an academic researcher from Institut national de la recherche agronomique. The author has contributed to research in topics: Population & Chemistry. The author has an hindex of 15, co-authored 57 publications. Previous affiliations of Human Rezaei include Université Paris-Saclay.
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Papers
Binding of methylene blue to a surface cleft inhibits the oligomerization and fibrillization of prion protein.
Paola Cavaliere,Joan Torrent,Stéphanie Prigent,Vincenzo Granata,Kris Pauwels,Annalisa Pastore,Human Rezaei,Adriana Zagari +7 more
TL;DR: In vitro results allowed to surmise a mechanism of action in which the MB binding to PrP surface markedly interferes with the pathway towards oligomers and fibres, and MB could be considered as a general anti-aggregation compound, acting against proteinopathies.
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Glycan-Controlled Epitopes of Prion Protein Include a Major Determinant of Susceptibility to Sheep Scrapie
Mohammed Moudjou,Eric Treguer,Human Rezaei,Elifsu Sabuncu,Erdmute Neuendorf,Martin H. Groschup,Jeanne Grosclaude,Hubert Laude +7 more
TL;DR: Four novel glycoform-dependent monoclonal antibodies raised against prokaryotic recombinant sheep PrP are characterized, demonstrating that these antibodies discriminate the PrP monoglycosylated species, and proposing that each glycan chain controls the accessibility of PrP determinants located close upstream from their attachment site.
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Proteinase K-Resistant Material in ARR/VRQ Sheep Brain Affected with Classical Scrapie Is Composed Mainly of VRQ Prion Protein
J. G. Jacobs,Alex Bossers,Human Rezaei,L.J.M. van Keulen,Sandra McCutcheon,Theodoros Sklaviadis,Isabelle Lantier,Patricia Berthon,Frédéric Lantier,F.G. van Zijderveld,Jan P. M. Langeveld +10 more
TL;DR: Investigation of whether the ARR allele substantially contributes to scrapie prion formation in naturally infected heterozygous 171Q/R animals found a nearly zero contribution, suggestive of a poor adaptation of classical scrapie to this resistance allele under these natural conditions.
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Absence of Evidence for a Causal Link between Bovine Spongiform Encephalopathy Strain Variant L-BSE and Known Forms of Sporadic Creutzfeldt-Jakob Disease in Human PrP Transgenic Mice
Emilie Jaumain,Isabelle Quadrio,Laetitia Herzog,Fabienne Reine,Human Rezaei,Olivier Andreoletti,Hubert Laude,Armand Perret-Liaudet,Stéphane Haïk,Vincent Béringue +9 more
TL;DR: Extrapolation of the results suggests that L-BSE may propagate in humans as an unrecognized form of CJD, and it is urged to continue the continued utilization of precautionary measures to eliminate these agents from the human food chain and active surveillance for CJD phenotypes in the general population.
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Decrypting Prion Protein Conversion into a β-Rich Conformer by Molecular Dynamics
Nesrine Chakroun,Arianna Fornili,Stéphanie Prigent,Jens Kleinjung,Cécile A. Dreiss,Human Rezaei,Franca Fraternali +6 more
TL;DR: The results presented here confirm the importance of the H2H3 domain for prion oligomer formation and therefore its potential use as molecular target in the design of novel prion inhibitors.
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