HuiSong Pak
Ludwig Institute for Cancer Research
30 Papers
40 Citations
HuiSong Pak is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Human leukocyte antigen & Chemistry. The author has an hindex of 8, co-authored 18 publications. Previous affiliations of HuiSong Pak include University of Lausanne & University Hospital of Lausanne.
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Papers
Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.
Chloe Chong,Chloe Chong,Markus Müller,HuiSong Pak,HuiSong Pak,Dermot Harnett,Florian Huber,Florian Huber,Delphine Grun,Marion Leleu,Marion Leleu,Aymeric Auger,Marion Arnaud,Marion Arnaud,Brian Stevenson,Justine Michaux,Justine Michaux,Ilija Bilic,Antje Hirsekorn,Lorenzo Calviello,Laia Simó-Riudalbas,Evarist Planet,Jan Lubinski,Jan Lubinski,Marta Ewa Bryśkiewicz,Marta Ewa Bryśkiewicz,Maciej Wiznerowicz,Maciej Wiznerowicz,Ioannis Xenarios,Ioannis Xenarios,Lin Zhang,Didier Trono,Alexandre Harari,Alexandre Harari,Uwe Ohler,Uwe Ohler,George Coukos,George Coukos,Michal Bassani-Sternberg,Michal Bassani-Sternberg +39 more
TL;DR: The authors integrate exome sequencing, transcriptomics, ribosome profiling, and immunopeptidomics to identify tumor-specific non-canonical HLA-bound peptides, including an immunogenic peptide derived from an open reading frame downstream of the melanoma stem cell marker gene ABCB5.
Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity.
Michal Bassani-Sternberg,Chloe Chong,Chloe Chong,Philippe Guillaume,Philippe Guillaume,Marthe Solleder,Marthe Solleder,HuiSong Pak,HuiSong Pak,Philippe O. Gannon,Lana E. Kandalaft,Lana E. Kandalaft,George Coukos,George Coukos,David Gfeller,David Gfeller,David Gfeller +16 more
TL;DR: The approach recapitulates and refines known motifs for 43 of the most frequent alleles, uncovers new motifs and provides a scalable framework to incorporate additional HLA peptidomics studies in the future and improves neo-antigen and cancer testis antigen predictions.
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The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands.
David Gfeller,David Gfeller,Philippe Guillaume,Justine Michaux,HuiSong Pak,Roy Thomas Daniel,Julien Racle,Julien Racle,George Coukos,Michal Bassani-Sternberg +9 more
TL;DR: Explicitly modeling peptide length distribution and multiple specificity improved predictions of naturally presented HLA-I ligands, as demonstrated in an independent benchmarking based on the new human meningioma samples.
The length distribution and multiple specificity of naturally presented HLA-I ligands
David Gfeller,Philippe Guillaume,Justine Michaux,HuiSong Pak,Roy Thomas Daniel,Julien Racle,George Coukos,Michal Bassani-Sternberg +7 more
TL;DR: Explicitly modeling peptide length distribution and multiple specificity improved predictions of naturally presented HLA-I ligands, as demonstrated in an independent benchmarking based on the new human meningioma samples.
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
Abhijeet Pataskar,Julien Champagne,Remco Nagel,Juliana C.N. Kenski,Maarja Laos,Justine Michaux,HuiSong Pak,Onno B. Bleijerveld,Kelly Mordente,J.M. Navarro,N. Blommaert,Morten M. Nielsen,Domenica Lovecchio,Everett Stone,George Georgiou,Mark C. de Gooijer,Olaf van Tellingen,Maarten Altelaar,Robbie P. Joosten,Anastassis Perrakis,Johanna Olweus,Michal Bassani-Sternberg,Daniel S. Peeper,Reuven Agami +23 more
TL;DR: In this article , the authors identified tryptophan-to-phenylalanine codon reassignment (W>F) as the major event facilitating this process, and pinpointed T cells secrete interferon-γ to upregulate the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme.