Huimin Yan
Washington University in St. Louis
43 Papers
176 Citations
Huimin Yan is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 18, co-authored 34 publications. Previous affiliations of Huimin Yan include Peking Union Medical College & Veterans Health Administration.
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Papers
Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury
Huimin Yan,Xin Duan,Hua Pan,Nilsson Holguin,Muhammad Farooq Rai,Antonina Akk,Luke E. Springer,Samuel A. Wickline,Linda J. Sandell,Christine T. N. Pham +9 more
TL;DR: It is shown that the peptide–siRNA nanocomplexes are nonimmunogenic, are freely and deeply penetrant to human OA cartilage, and persist in chondrocyte lacunae for at least 2 wk, and provides a clinically relevant and promising approach to overcoming the obstacles of drug delivery to the highly inaccessible chondROcytes.
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Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation
Huimin Yan,Hui-fang Zhou,Antonina Akk,Ying Hu,Luke E. Springer,Terri L. Ennis,Christine T. N. Pham +6 more
TL;DR: These results suggest that neutrophil protease–mediated NET release contributes to elastase-induced AAA through pDC activation and type I IFN production and suggest that limiting NET, pDC, and typeI IFN activities may suppress aneurysm progression.
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Targeting TLR2 attenuates pulmonary inflammation and fibrosis by reversion of suppressive immune microenvironment.
TL;DR: It is suggested that TLR2 is a promising target for the development of therapeutic agents against pulmonary fibrosis and that eliminating immunosuppressive cells and factors via immunostimulants is a novel strategy for fibro-proliferative diseases.
Blocking TLR2 activity attenuates pulmonary metastases of tumor
Hong-Zhen Yang,Bing Cui,Han Zhi Liu,Su Mi,Jun Yan,Huimin Yan,Fang Hua,Heng Lin,Wenfeng Cai,Wen-Jie Xie,Xiao Xi Lv,Xiao-xing Wang,Bing Mu Xin,Qi Min Zhan,Zhuo-Wei Hu +14 more
TL;DR: The results demonstrate that TLR2 is an attractive target against metastasis and that targeting immunosuppressive microenvironment using anti-TLR2 antibody is a novel therapeutic strategy for combating a life-threatening metastasis.
Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide
Hui Fang Zhou,Huimin Yan,Ying Hu,Luke E. Springer,Xiaoxia Yang,Samuel A. Wickline,Dipanjan Pan,Gregory M. Lanza,Christine T. N. Pham +8 more
TL;DR: Evidence is presented that Fum-PD nanotherapy indirectly suppresses inflammation in experimental RA through the local production of endothelial nitric oxide (NO) and reverses the suppression of NF-κB-mediated inflammatory response induced by Fum, PD nanotherapy.
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