Hui Yu
University of Pittsburgh
22 Papers
314 Citations
Hui Yu is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 14, co-authored 22 publications.
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Papers
Hematopoietic stem cell exhaustion impacted by p18INK4C and p21Cip1/Waf1 in opposite manners
TL;DR: New insights are provided into the distinct impacts of these cell-cycle regulators on HSC exhaustion and possibly HSC aging as well under proliferative stress, thereby offering potential pharmacologic targets for sustaining the durability of stressed HSCs in transplantation or elderly patients.
142
Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose γ-irradiation
Hui Yu,Hongmei Shen,Youzhong Yuan,Richard XuFeng,Xiaoxia Hu,Sean P. Garrison,Lin Zhang,Jian Yu,Gerard P. Zambetti,Tao Cheng,Tao Cheng +10 more
TL;DR: It is demonstrated that Puma is a unique mediator in radiation-induced death of HSCs, and may be a potential target for developing an effective treatment aimed to protect H SCs from lethal radiation.
135
Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer.
Li-Ying Sung,Shaorong Gao,Hongmei Shen,Hui Yu,Yifang Song,Sadie L. Smith,Ching-Chien Chang,Kimiko Inoue,Lynn Kuo,Jin Lian,Ao Li,X. Cindy Tian,David Tuck,Sherman M. Weissman,Xiangzhong Yang,Tao Cheng +15 more
TL;DR: It is found that cloning efficiency increases over the differentiation hierarchy, and terminally differentiated postmitotic granulocytes yield cloned pups with the greatest cloning efficiency.
132
ADAR1 is required for hematopoietic progenitor cell survival via RNA editing
Richard XuFeng,Matthew J. Boyer,Hongmei Shen,Yanxin Li,Hui Yu,Yindai Gao,Qiong Yang,Qingde Wang,Tao Cheng +8 more
TL;DR: It is shown that ADAR1 is required for survival of differentiating HPCs as opposed to more primitive cells in adult mice by multiple strategies targeting floxed ADar1 for deletion by Cre recombinase, and direct evidence is obtained thatADAR1 functions in H PCs via an RNA-editing dependent mechanism.
114
The p53–PUMA axis suppresses iPSC generation
Yanxin Li,Haizhong Feng,Haihui Gu,Dale W. Lewis,Youzhong Yuan,Lei Zhang,Hui Yu,Peng Zhang,Haizi Cheng,Weimin Miao,Weiping Yuan,Shi Yuan Cheng,Susanne M. Gollin,Tao Cheng,Tao Cheng +14 more
TL;DR: It is demonstrated that PUMA is an independent mediator of the negative effect of p53 on induced pluripotent stem cell induction and may serve as a distinct and more desirable target in the p53 pathway for induced plurine stem cell generation, thereby having important implications for potential therapeutic applications of induced plurIPotent stem cells.