Hui Yang
Hong Kong Baptist University
20 Papers
177 Citations
Hui Yang is an academic researcher from Hong Kong Baptist University. The author has contributed to research in topics: Chemistry & DNA. The author has an hindex of 16, co-authored 20 publications.
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Papers
Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer.
Daniel Shiu-Hin Chan,Hui Yang,Maria Hiu-Tung Kwan,Zhen Cheng,Paul Lee,Li-Ping Bai,Zhi-Hong Jiang,Chun-Yuen Wong,Wang-Fun Fong,Chung-Hang Leung,Dik-Lung Ma +10 more
TL;DR: High-throughput virtual screening is used to identify FDA-approved drug methylene blue (MB) as a promising scaffold for binding the c-myc oncogene G-quadruplex DNA and to identify MB derivatives containing side chains that could interact with the G- quadruplex grooves.
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Label-free detection of sub-nanomolar lead(II) ions in aqueous solution using a metal-based luminescent switch-on probe
Hong-Zhang He,Ka-Ho Leung,Hui Yang,Daniel Shiu-Hin Chan,Chung-Hang Leung,Jun Zhou,Anne Bourdoncle,Anne Bourdoncle,Jean-Louis Mergny,Dik-Lung Ma +9 more
TL;DR: A label-free oligonucleotide-based luminescent switch-on assay has been developed for the selective detection of sub-nanomolar Pb(2+) ions in aqueous solution and real water samples and exhibits good selectivity for P b( 2+) ions over other heavy metal ions.
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A selective G-quadruplex-based luminescent switch-on probe for the detection of nanomolar silver(I) ions in aqueous solution.
Bradley Yat-Wah Man,Daniel Shiu-Hin Chan,Daniel Shiu-Hin Chan,Hui Yang,Si-Wo Ang,Fang Yang,Siu-Cheong Yan,Chi-Ming Ho,Peng Wu,Chi-Ming Che,Chung-Hang Leung,Dik-Lung Ma +11 more
TL;DR: A G-quadruplex-based luminescent platinum(II) switch-on probe has been developed for the selective detection of nanomolar Ag(+) ions in aqueous solution.
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A label-free G-quadruplex-based switch-on fluorescence assay for the selective detection of ATP
Hong-Zhang He,Victor Pui-Yan Ma,Ka-Ho Leung,Daniel Shiu-Hin Chan,Hui Yang,Zhen Cheng,Chung-Hang Leung,Dik-Lung Ma +7 more
TL;DR: A G-quadruplex-based, label-free, switch-on fluorescence detection method has been developed for the selective detection of ATP in aqueous solution using crystal violet as a G- quadruple-selective probe.
Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library.
Dik-Lung Ma,Daniel Shiu-Hin Chan,Guo Wei,Hai-Jing Zhong,Hui Yang,Lai To Leung,Elizabeth A. Gullen,Pauline Chiu,Yung-Chi Cheng,Chung-Hang Leung +9 more
TL;DR: In silico optimization using the DOLPHIN model yielded analogues with enhanced potency against JAK2 activity and HCV activity in cellulo that suggested that the analogues may function as Type II inhibitors ofJAK2.
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