12 Papers
32 Citations
Hui Wen is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Cystic fibrosis transmembrane conductance regulator & Biology. The author has an hindex of 7, co-authored 9 publications.
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Papers
Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis
Jennifer S. Guimbellot,Stephen W. Erickson,Tapan Mehta,Hui Wen,Grier P. Page,Eric J. Sorscher,Jeong S. Hong +6 more
TL;DR: The data suggest the physiologic impact of miRNAs on cellular transcription results from a multifaceted network of miRNA and mRNA relationships, working together in an interconnected system and in context of hundreds of RNA species.
hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells
TL;DR: In this paper , the authors show that HnRNPH1 is highly expressed in the reproductive system and recruits the PTBP2 and SRSF3 to modulate the alternative splicing in germ cells.
Micro-RNA-like effects of complete intronic sequences.
Aubrey E. Hill,Jeong S. Hong,Hui Wen,LiHong Teng,David T. McPherson,Sylvia A. McPherson,Dana N. Levasseur,Eric J. Sorscher +7 more
TL;DR: Gene chip array data is presented indicating that in the absence of miRNA sequences, complete human introns are similarly capable of coordinating expression of large numbers of gene products at spatially diverse sites within the genome.
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S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment
TL;DR: Recombinant expression of specific PATs led to increased levels of CFTR protein and enhanced palmitoylation as judged by Western blot and metabolic labelling, pointing to the importance of palMIToylation during wild-type and F508del CFTR trafficking.
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The synthetic aminoglycoside ELX-02 induces readthrough of G550X-CFTR producing superfunctional protein that can be further enhanced by CFTR modulators
Jianguo Chen,Kari Thrasher,Lianwu Fu,Wei Wang,Soheil Aghamohammadzadeh,Hui Wen,Li Ping Tang,Kim M. Keeling,Emily Falk Libby,David M. Bedwell,Steven M. Rowe +10 more
TL;DR: In this paper , the authors examined readthrough of the rare G550X-CFTR nonsense mutation due to its unique properties and found that forskolin-induced swelling in patient-derived intestinal organoids (PDOs) was significantly higher than in G542X PDOs (both UGA PTCs) with ELX-02 treatment.