Hui Wang
Stony Brook University
14 Papers
74 Citations
Hui Wang is an academic researcher from Stony Brook University. The author has contributed to research in topics: Amyloid & Amylin. The author has an hindex of 12, co-authored 14 publications.
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Papers
Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity
Ping Cao,Peter Marek,Harris Noor,Vadim Patsalo,Ling Hsien Tu,Hui Wang,Andisheh Abedini,Daniel P. Raleigh +7 more
TL;DR: Islet amyloid is not the cause of type 2 diabetes, but it leads to β‐cell dysfunction and cell death, and contributes to the failure of islet cell transplantation.
184
Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
Andisheh Abedini,Annette Plesner,Ping Cao,Zachary Ridgway,Jinghua Zhang,Ling Hsien Tu,Chris T. Middleton,Brian Chao,Daniel J. Sartori,Fanling Meng,Hui Wang,Amy G. Wong,Martin T. Zanni,C. Bruce Verchere,Daniel P. Raleigh,Ann Marie Schmidt +15 more
TL;DR: The toxic species produced during IAPP amyloid formation are defined and their properties linked to induction of rat INS-1 β-cell and murine islet toxicity are linked, highlighting the distinguishing properties of toxic IAPP oligomers and the common features that they share with toxic species reported for other amyloidsogenic polypeptides.
Islet amyloid polypeptide toxicity and membrane interactions
Ping Cao,Andisheh Abedini,Hui Wang,Ling Hsien Tu,Xiaoxue Zhang,Ann Marie Schmidt,Daniel P. Raleigh +6 more
TL;DR: Biophysical measurements in conjunction with cytotoxicity studies show that nonamyloidogenic rat IAPP is as effective as human IAPP at disrupting standard anionic model membranes under conditions whereRat IAPP does not induce cellular toxicity.
146
Amyloid Formation in Heterogeneous Environments: Islet Amyloid Polypeptide Glycosaminoglycan Interactions
TL;DR: It is shown that variants of islet amyloid polypeptide (IAPP), which are non-amyloidogenic in homogeneous solution, can be readily induced to form amyloids in the presence of glycosaminoglycans (GAGs).
29
General Amyloid Inhibitors? A Critical Examination of the Inhibition of IAPP Amyloid Formation by Inositol Stereoisomers
Hui Wang,Daniel P. Raleigh +1 more
TL;DR: This work investigates the ability of inositol stereoisomers to inhibit amyloid formation by IAPP and provides a basis for comparison to work on polyphenol based inhibitors of IAPP amyloids formation and helps provide clues as to the features which render them effective.