6 Papers
32 Citations
Hui Wang is an academic researcher from Shenyang Pharmaceutical University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 3, co-authored 3 publications.
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Papers
Facile synthesis and cytotoxicity of triterpenoid saponins bearing a unique disaccharide moiety: hederacolchiside A1 and its analogues
TL;DR: An improved synthetic approach toward hederacolchiside A1, an antitumor triterpenoid saponin bearing a unique disaccharide moiety, was established from a partially protected intermediate and avoided tedious protection-deprotection manipulation.
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Synthesis, antitumor activity evaluation and mechanistic study of novel hederacolchiside A1 derivatives bearing an aryl triazole moiety.
TL;DR: The mechanistic study of 4f revealed that this compound can induce cell apoptosis in HepG2 cells via mitochondrial-mediated intrinsic pathways and showed a 2- to 7-fold more potent activity than hederacolchiside A1.
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Synthesis of bisdesmosidic kryptogenyl saponins using the ‘random glycosylation’ strategy and evaluation of their antitumor activity
TL;DR: A bisdesmosidic steroidal saponins library, composed of 16 novel kryptogenin glycosides, was set up via six random glycosylation procedures, wherein two compounds showed their antitumor activity against HeLa cell in the preliminary pharmacological research.
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Nonlinear dynamic optimization of marine riser system anti-recoil under a flexible multibody framework
TL;DR: In this paper , a nonlinear dynamic optimization model and solution method of a marine riser system anti-recoil under a flexible multibody framework is proposed, and the objective and constraint functions are elaborately designed to protect the system from dynamic buckling and wellhead and riser collision.
6
Synthesis of Lathyrol PROTACs and Evaluation of Their Anti-Inflammatory Activities.
Wei Wang,Yang Liu,Liangliang Xiong,Dejuan Sun,Hui Wang,Zhuorui Song,Yutong Li,Hua Ling Li,Lixia Chen +8 more
TL;DR: In this article , compound 13 exhibited inhibitory activity on LPS-induced NO production in RAW264.7 cells (IC50 = 5.30 ± 1.23 μM) with low cytotoxicity.