Hui Su
Novartis
6 Papers
112 Citations
Hui Su is an academic researcher from Novartis. The author has contributed to research in topics: Histone methyltransferase & DNA methylation. The author has an hindex of 5, co-authored 6 publications.
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Papers
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
Jing Wang,Sarah Hevi,Julia K. Kurash,Hong Lei,Jeffrey Bajko,Hui Su,Weitao Sun,Hua Chang,Guoliang Xu,François Gaudet,En Li,Taiping Chen +11 more
TL;DR: It is suggested that LSD1 demethylates and stabilizes Dnmt1, thus providing a previously unknown mechanistic link between the histone and DNA methylation systems.
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The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.
Brendan Jones,Hui Su,Audesh Bhat,Hong Lei,Jeffrey Bajko,Sarah Hevi,Gretchen A. Baltus,Shilpa Kadam,Huili Zhai,Reginald Valdez,Susana Gonzalo,Yi Zhang,Yi Zhang,En Li,Taiping Chen +14 more
TL;DR: Results indicate that Dot1L and H3K79 methylation play important roles in heterochromatin formation and in embryonic development.
KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation.
Felix Lohmann,Joseph Loureiro,Hui Su,Qing Fang,Hong Lei,Tanya Lewis,Yi Yang,Mark Labow,En Li,Taiping Chen,Shilpa Kadam +10 more
TL;DR: It is demonstrated that conditional deletion of the Setdb1 gene in ES cells results in the upregulation of lineage differentiation markers, especially trophectoderm‐specific factors, similar to effects observed upon loss of Oct3/4 expression in ES Cells.
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A hypomorphic lsd1 allele results in heart development defects in mice.
Thomas B. Nicholson,Anup Kumar Singh,Hui Su,Sarah Hevi,Jing Wang,Jeff Bajko,Mei Li,Reginald Valdez,Margaret Goetschkes,Paola Capodieci,Joseph Loureiro,Xiaodong Cheng,En Li,Bernd Kinzel,Mark Labow,Taiping Chen +15 more
TL;DR: A hypomorphic Lsd1 allele that contains two point mutations in the tower domain is described, resulting in a protein with reduced interaction with known binding partners and decreased enzymatic activity, identifying a previously unknown role for LSD1 in heart development.
Defective heart development in hypomorphic LSD1 mice.
Thomas B. Nicholson,Hui Su,Sarah Hevi,Jing Wang,Jeff Bajko,Mei Li,Reginald Valdez,Joseph Loureiro,Xiaodong Cheng,En Li,Bernd Kinzel,Mark Labow,Taiping Chen +12 more
TL;DR: A hypomorphic LSD1 allele that contains two point mutations in the tower domain is described, resulting in a protein with reduced interaction with known binding partners and decreased enzymatic activity, identifying a previously unknown role for LSD1 in heart development.