Recent development of fiber-optic chemical sensors and biosensors: Mechanisms, materials, micro/nano-fabrications and applications

Food safety affects everyone worldwide and will remain a global challenge to human health in the foreseeable future requiring the rapid, sensitive, efficient and inexpensive detection of food contaminants. Biosensors have long been investigated to be part of a solution. In fact, current research trends of nanoscale science and technology, efforts of miniaturization and connectivity enabled through the internet of things boost biosensors’ capabilities to a degree that they surely will play a major part of the answer to this global challenge. Surprisingly though, the adaption of such biosensors to function along the entire food value chain and hence also include important aspects of sustainable agriculture and food fraud has been neglected so far. In this review, the latest developments of biosensors addressing these issues are presented for the years 2015–2019 and point toward important new strategies needed to truly ensure safe food in a sustainable global market.

Biosensors to support sustainable agriculture and food safety

A singlemode-multimode-singlemode (SMS) fiber structure consists of a short section of multimode fiber fusion- spliced between two SMS fibers. The mechanism underpinning the operation of an SMS fiber structure is multimode interference and associated self-imaging. SMS structures can be used in a variety of optical fiber systems but are most commonly used as sensors for a variety of parameters, ranging from macro-world measurands such as temperature, strain, vibration, flow rate, RI and humidity to the micro-world with measurands such as proteins, pathogens, DNA and specific molecules. While traditional SMS structures employ a short section of standard multimode fiber, a large number of structures have been investigated and demonstrated over the last decade involving the replacement of the multimode fiber section with alternatives such as a hollow core fiber or a tapered fiber. The objective of replacing the multimode fiber has most often been to allow sensing of different measurands or to improve sensitivity. In this paper, several different categories of SMS fiber structures, including traditional SMS, modified SMS and tapered SMS fiber structures are discussed with some theoretical underpinning and reviews of a wide variety of sensing examples and recent advances. The paper then summarizes and compares the performances of a variety of sensors which have been published under a number of headings. The paper concludes by considering the challenges faced by SMS based sensing schemes in terms of their deployment in real world applications and discusses possible future developments of SMS fiber sensors.

/pdf/singlemode-multimode-singlemode-fiber-structures-for-sensing-414kj1fml3.pdf

Singlemode-Multimode-Singlemode Fiber Structures for Sensing Applications—A Review

Applications of fiber-optic biochemical sensor in microfluidic chips: A review.

A novel optical fiber glucose biosensor based on carbon quantum dots-glucose oxidase/cellulose acetate complex sensitive film.

Escherichia coli bacteria have been found to be responsible for various health outbreaks caused by contaminated food and water. Accurate and rapid test of E. coli is thus crucial for protecting the public health. A fast-response, label-free bacteriophage-based detection of E. coli using multimode microfiber probe is proposed and demonstrated in this article. Due to the abrupt taper and subwavelength diameter, different modes are excited and guided in the microfiber as evanescent field that can interact with surrounding E. coli directly. The change of E. coli concentration and corresponding binding of E. coli bacteria on microfiber surface will lead to the shift of optical spectrum, which can be exploited for the application of biosensing. The proposed method is capable of reliable detection of E. coli concentration as low as 103 cfu/mL within the range of 103 to 107  cfu/mL. Owing to the advantages of high sensitivity and fast response, the microfiber probe has great potential application in the fields of environment monitoring and food safety.

Selective and sensitive Escherichia coli detection based on a T4 bacteriophage-immobilized multimode microfiber.

AIM
To establish a fast, sensitive and accurate high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for determining the monosaccharide content of Qingzhuan Dark Tea polysaccharides in different years (2 years, 5 years and 11 years).


METHODS
The optimised chromatographic conditions were achieved on a C18 column (5.0 μm, 250 mm × 4.6 mm inner diameter). The mobile phase flow rate was 0.9 mL/min and the column temperature was set to 27°C. The aqueous phase A (5 mM aqueous ammonium acetate) and organic phase B (acetonitrile) were used to elute the target analyses isocratically (0-60 min: 18% B). The mass spectrometer detector was equipped with an electron spray ionisation (ESI)source, and multiple reaction monitoring (MRM) mode was used for the determination of 1-phenyl-3-methyl-5-pyrazolone (PMP) derived monosaccharides.


RESULTS
We carried out a comprehensive methodological validation of PMP derived monosaccharides, including linearity, precision, stability and repeatability. Nine monosaccharides (rhamnose, mannose, ribose, glucose, galacturonic acid, xylose, galactose, fucose and arabinose) of Qingzhuan Dark Tea polysaccharides were identified, in which ribose and fucose were reported for the first time. The results showed the contents of these nine monosaccharides differed significantly among different years.


CONCLUSIONS
The validated method is reliable, accurate, repeatable and can be applied to quality assessment of these monosaccharides.

The determination of monosaccharide in different years Qingzhuan Dark Tea polysaccharide by liquid chromatography-mass spectrometry.

Escherichia coli (E.coli) bacteria have been found to be responsible for various health outbreaks caused by contaminated food and water. Accurate and rapid test of E.coli is thus crucial for protecting the public health. A fast-response, label-free bacteriophage-based detection of E.coli using multimode microfiber probe is proposed and demonstrated in this paper. Due to the abrupt taper and subwavelength diameter, different modes are excited and guided in the microfiber as evanescent field that can interact with surrounding E.coli directly. The change of E.coli concentration and corresponding binding of E.coli bacteria on microfiber surface will lead to the shift of optical spectrum, which can be exploited for the application of biosensing. The proposed method is capable of reliable detection of E.coli concentration as low as 103cfu/ml within the range of 103-107cfu/ml. Owing to the advantages of high sensitivity and fast response, the microfiber probe has great potential application in the fields of environment monitoring and food safety.

Immobilized optical fiber microprobe for selective and sensitive Escherichia coli detection

Optical fiber microprobe functionalized with Glucose oxidase (GOD) has been proposed for bio-selective and high-sensitive glucose detection Taking advantages of the free amine groups of 3-aminopropyl- triethoxysilane (APTES), the enzymes (GOD) are immobilized on the multimode microfiber through covalent interaction Surface characterization offered by optical microscopy, scanning electron microscope and multiphoton laser scanning microscopy provide detailed evidences about the effect of the bio-functionalization The fabricated microfiber sensor is immersed into glucose solutions at different concentrations to record and analyze the transmission spectrums from an optical sensing interrogator The experimental results demonstrate that the resonant wavelength shift is linearly correlated with the glucose concentration in the range of 0–30 mg/ml with a response coefficient of 174 nm/mg −1  ml −1  Meanwhile, the reported sensor is also proved to be of practical utility by accurately detecting glucose content in animal serum samples Due to the small size, label-free sensing capacity and excellent practicality, the proposed device has great potential to be applied in the fields like disease diagnosis, clinical analysis and food safety

Immobilized optical fiber microprobe for selective and high sensitive glucose detection

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Hui Ma

Author Tools

Chat about Author

Papers

Selective and sensitive Escherichia coli detection based on a T4 bacteriophage-immobilized multimode microfiber.

The determination of monosaccharide in different years Qingzhuan Dark Tea polysaccharide by liquid chromatography-mass spectrometry.

Immobilized optical fiber microprobe for selective and sensitive Escherichia coli detection

Immobilized optical fiber microprobe for selective and high sensitive glucose detection