Objective: The objective of the present study was to meta-analyze relevant literature to gain a comprehensive understanding of the potential relationship between serum uric acid levels and risk of benign paroxysmal positional vertigo (BPPV). Methods: The databases of PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed were systematically searched for observational case-control studies of the association between BPPV and serum uric acid levels published up to October 2018. Data from eligible studies were meta-analyzed using Stata 12.0. Results: A total of 12 studies were included in the analysis. There was a strong tendency for serum uric acid levels to be associated with risk of BPPV among studies conducted in China (OR 0.69, 95%CI -0.01 to 1.40, p = 0.053), but not among studies outside China (OR 1.07, 95%CI -1.08 to 3.22, p = 0.33). Across all studies, serum uric acid level was significantly higher among individuals with BPPV than among controls (OR 0.78, 95%CI 0.15 to 1.41, p = 0.015), yet it did not independently predict risk of the disorder (OR 1.003, 95%CI 0.995 to 1.012, p = 0.471). Conclusion: The available evidence suggests that BPPV is associated with elevated levels of serum uric acid, but these levels may not be an independent risk factor of BPPV.

/pdf/association-between-serum-uric-acid-levels-and-benign-16c05j1g44.pdf

Association Between Serum Uric Acid Levels and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis of Observational Studies.

Objective
To investigate the relationship between benign paroxysmal positional dizziness (BPPV) and cerebrovascular disease and to promotethe practice of evidence-bases medicinein thediagnosis, treatment and recurrenceprevention of BPPV in the elderly.


Methods
A total of 80 elderly patients were consecutively recruited from the Dizziness Outpatient Clinic from January 2013 to June, 2014, with 80 non-BPPV elderly individuals receiving routine physical checkups during the same period serving as the control group.Clinical characteristics, lab test results and imaging data were compared between the two groups.Single factor and multivariate logistic regression analyses were conducted to identify independent risk factors for BPPV in the elderly.


Results
The experimental group showed higher rates of lacunar infarction, leukoaraiosis and intracranial artery stenosis than the control group(χ2=10.180, 4.606 and 3.956, respectively; P=0.001, 0.032 and 0.047, respectively). The prevalences of hyperlipidemia and type 2 diabetes were higher in the BPPV group than in the control group(χ2=5.013 and 6.041, respectively; P=0.025 and 0.014, respectively). Differences in number of carotid atherosclerotic plaque cases, total cholesterol, triglyceride, homocysteine and uric were found between the two groups (χ2=11.237, t=2.862, 2.230 and 4.270, respectively; P=0.001, 0.005, 0.027 and 0.000, respectively). Multivariate logistic regression analysisfound that blood uric acid, hyperglycemia, type 2 diabetes and hypertension were independent risk factors for BPPV (OR=1.006, 7.104, 3.152 and 3.273, respectively; P=0.005, 0.000, 0.004 and 0.002, respectively). The existence of carotid atherosclerotic plaques also increased the risk of BPPV(OR=384.570, 95%CI: 46.935~3151.055, P=0.000).


Conclusions
BPPV in the elderlyis closely associated with cerebrovascular disease and its risk factors.Therefore, it is of great clinical significance to assess cerebrovascular function and carotid atherosclerotic plaque development for improved prognosis and effective prevention of recurrence of BPPV in the elderly.


Key words: 
Vertigo; Cerebrovascular disorders

The relationship between benign paroxysmal positional vertigo and cerebrovascular disease in the elderly

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The relationship between benign paroxysmal positional vertigo and cerebrovascular disease in the elderly