Hui Li
Shandong University
6 Papers
53 Citations
Hui Li is an academic researcher from Shandong University. The author has contributed to research in topics: Phosphatase & Signal transduction. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Hui Li include Protein Sciences.
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Papers
Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer.
Amritha Nair,Hsiang Ching Chung,Tingting Sun,Siddhartha Tyagi,Lacey E. Dobrolecki,Rocio Dominguez-Vidana,Sarah J. Kurley,Mayra Orellana,Alexander Renwick,David M. Henke,Panagiotis Katsonis,Earlene M. Schmitt,Doug W. Chan,Hui Li,Sufeng Mao,Ivana Petrovic,Chad J. Creighton,Carolina Gutierrez,Julien Dubrulle,Fabio Stossi,Jeffrey W. Tyner,Olivier Lichtarge,Charles Y. Lin,Bing Zhang,Kenneth L. Scott,Susan G. Hilsenbeck,Jin-Peng Sun,Xiao Yu,C. Kent Osborne,Rachel Schiff,James G. Christensen,David J. Shields,Mothaffar F. Rimawi,Matthew J. Ellis,Chad A. Shaw,Michael T. Lewis,Thomas F. Westbrook +36 more
TL;DR: A broadly effective therapeutic strategy for TNBC that is based on combined inhibition of receptors that share the negative regulator PTPN12 and rationalized a combination RTK-inhibitor therapy that induced potent tumor regression across heterogeneous models of TNBC, suggesting that impaired receptor feedback may establish a combined addiction to these proto-oncogenic receptors.
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Different downstream signalling of CCK1 receptors regulates distinct functions of CCK in pancreatic beta cells
Shanglei Ning,Shanglei Ning,Wenshuai Zheng,Wenshuai Zheng,Jing Su,Jing Su,Nan Liang,Nan Liang,Hui Li,Hui Li,Dao-lai Zhang,Dao-lai Zhang,Chun-Hua Liu,Chun-Hua Liu,Jun-hong Dong,Jun-hong Dong,Zheng-kui Zhang,Min Cui,Qiao-Xia Hu,Qiao-Xia Hu,Chao-chao Chen,Chao-chao Chen,Chang-hong Liu,Chuan Wang,Qi Pang,Yuxin Chen,Xiao Yu,Jin-Peng Sun +27 more
TL;DR: In this paper, the sulfated carboxy-terminal octapeptide CCK26-33 amide (CCK-8s) activated CCK1 receptors and induced accumulation of both IP3 and cAMP.
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Crystal Structure and Substrate Specificity of PTPN12.
Hui Li,Fan Yang,Chun-Hua Liu,Peng Xiao,Yunfei Xu,Zong-Lai Liang,Chuan Liu,Hong-Mei Wang,Wenjun Wang,Wenshuai Zheng,Wei Zhang,Xiaoyun Ma,Dongfang He,Xiaoyuan Song,Fu-ai Cui,Zhigang Xu,Fan Yi,Jin-Peng Sun,Xiao Yu +18 more
TL;DR: This work has identified two distinct structural features that are crucial determinants of PTPN12 substrate specificity: the pY+1 site binding pocket and specific basic charged residues along its surface loops and revealed a CDK2 phosphorylation site in a specific PTPn12 loop.
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Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways.
Hui Li,Duxiao Yang,Shanglei Ning,Yinghui Xu,Fan Yang,Rusha Yin,Taihu Feng,Shouqing Han,Lu Guo,Peng-Ju Zhang,Wenjie Qu,Renbo Guo,Chen Song,Peng Xiao,Chengjun Zhou,Zhigang Xu,Jin-Peng Sun,Xiao Yu +17 more
TL;DR: A new phosphorylation‐based substrate recognition mechanism of PTPN12 by CDK2, which orchestrated signaling crosstalk between the oncogenic CDK 2 and HER2 pathways is identified, which demonstrates how a phospho‐network is precisely controlled in different cellular contexts.
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Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot auto-inhibition and activation
Duxiao Yang,Peng Xiao,Qing Li,Xiao-Lei Fu,Chang Pan,Di Lu,Shi-shuai Wen,Wanying Xia,Dongfang He,Hui Li,Hao Fang,Yuemao Shen,Zhigang Xu,Amy Lin,Chuan Wang,Xiao Yu,Jia-Wei Wu,Jin-Peng Sun +17 more
TL;DR: The results reveal the auto-inhibitory mechanism and allosteric activation mechanisms of a human Slinghot phosphatase and contribute to the design of new strategies to study Slingshot regulation in various cellular contexts and to screen for new activators/inhibitors of Slingshots activity.
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