Hui Li
University of Virginia
61 Papers
198 Citations
Hui Li is an academic researcher from University of Virginia. The author has contributed to research in topics: Chimeric RNA & Gene. The author has an hindex of 24, co-authored 59 publications. Previous affiliations of Hui Li include Yale University & The Chinese University of Hong Kong.
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Papers
LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment.
Changhao Chen,Wang He,Jian Huang,Bo Wang,Hui Li,Qingqing Cai,Feng Su,Junming Bi,Hongwei Liu,Bin Zhang,Ning Jiang,Guangzheng Zhong,Yue Zhao,Wen Dong,Tianxin Lin +14 more
TL;DR: It is demonstrated that a long noncoding RNA LNMAT1 promotes LN metastasis of bladder cancer via recruitment of TAMs through epigenetic regulation of CCL2 expression, which provides a plausible mechanism for L NMAT1-modulated tumor microenvironment in lymphatic metastasis.
MET Amplification and Exon 14 Splice Site Mutation Define Unique Molecular Subgroups of Non-Small Cell Lung Carcinoma with Poor Prognosis.
Joanna H.M. Tong,Sai F. Yeung,Anthony W.H. Chan,Lau Y. Chung,Shuk L. Chau,Raymond W.M. Lung,Carol Y.K. Tong,Chit Chow,Edith K. Y. Tin,Yau H. Yu,Hui Li,Yi Pan,Wing Po Chak,Calvin S.H. Ng,Tony Mok,Ka F. To +15 more
TL;DR: The high incidence of METΔ14 mutation in sarcomatoid carcinoma suggested that MET inhibition might benefit this specific subgroup of patients and were independent prognostic factors that predicted poorer survival by multivariable analysis.
399
A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells.
TL;DR: It is shown that normal endometrial stromal cells contain a specific chimeric RNA joining 5′ exons of the JAZF1 gene on chromosome 7p15 to 3′ exon of the Polycomb group gene JJAZ1/SUZ12 on chromosome 17q11 and that this RNA is translated into J AZF1-JJAZ1, a protein with anti-apoptotic activity.
323
SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers
Hui Li,Lois Myeroff,Dominic J. Smiraglia,Michael F. Romero,Theresa P. Pretlow,Lakshmi Kasturi,James Lutterbaugh,Ronald M. Rerko,Graham Casey,Jean Pierre J. Issa,Joseph Willis,James K V Willson,Christoph Plass,Sanford D. Markowitz,Sanford D. Markowitz +14 more
TL;DR: Structural homology and functional testing demonstrated that SLC5A8 is a member of the family of sodium solute symporters, which is now added as a class of candidate colon cancer suppressor genes.
311
Recurrent chimeric fusion RNAs in non-cancer tissues and cells
Mihaela Babiceanu,Fujun Qin,Zhongqiu Xie,Yuemeng Jia,Kevin Lopez,Nick Janus,Loryn Facemire,Shailesh Kumar,Yuwei Pang,Yanjun Qi,Iulia M. Lazar,Hui Li +11 more
TL;DR: Performing functional analyses on a few widely expressed fusions found that silencing them resulted in dramatic reduction in normal cell growth and/or motility, and explored the implications of these non-pathological fusions in cancer and in evolution.