12 Papers
70 Citations
Hui Li is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Injector & Piston. The author has an hindex of 6, co-authored 12 publications. Previous affiliations of Hui Li include Fourth Military Medical University.
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Papers
A central neural circuit for itch sensation
Di Mu,Juan Deng,Kefei Liu,Zhen-Yu Wu,Yu-Feng Shi,Wei-Min Guo,Qun-Quan Mao,Xing-Jun Liu,Hui Li,Yan-Gang Sun +9 more
TL;DR: It is found that the spinoparabrachial pathway was activated during itch processing and that optogenetic suppression of this pathway impaired itch-induced scratching behaviors, revealing a central neural circuit that is critical for itch signal processing.
222
Descending Control of Itch Transmission by the Serotonergic System via 5-HT1A-Facilitated GRP-GRPR Signaling
Zhong Qiu Zhao,Xian-Yu Liu,Joseph Jeffry,W. K. Ajith Karunarathne,Jin-Lian Li,Admire Munanairi,Xuan-Yi Zhou,Hui Li,Hui Li,Yan-Gang Sun,Li Wan,Zhen-Yu Wu,Seung Il Kim,Fu-Quan Huo,Ping Mo,Ping Mo,Devin M. Barry,Chun-Kui Zhang,Ji-Young Kim,Narasimhan Gautam,Kenneth J. Renner,Yun-Qing Li,Zhou-Feng Chen +22 more
TL;DR: It is demonstrated that the descending 5-HT system facilitates GRP-GRPR signaling via 5-ht1A to augment itch-specific outputs, and a disruption of crosstalk between 5- HT1A and GRPR may be a useful antipruritic strategy.
121
dmPFC-vlPAG projection neurons contribute to pain threshold maintenance and antianxiety behaviors
Jun-Bin Yin,Shao-Hua Liang,Shao-Hua Liang,Fei Li,Wen-Jun Zhao,Yang Bai,Yang Bai,Yi Sun,Yi Sun,Yi Sun,Zhen-Yu Wu,Zhen-Yu Wu,Tan Ding,Yan Sun,Hai-Xia Liu,Ya-Cheng Lu,Ting Zhang,Jing Huang,Tao Chen,Hui Li,Hui Li,Zhou-Feng Chen,Jing Cao,Rui Ren,Ya-Nan Peng,Juan Yang,Wei-Dong Zang,Xiang Li,Yu-Lin Dong,Yun-Qing Li,Yun-Qing Li,Yun-Qing Li +31 more
TL;DR: The present results suggest that the dmPFC-vlPAG neural pathway might participate in the maintenance of pain thresholds and anxiolytic behaviors under normal conditions, while silencing or suppressing the dreary pathway might be involved in the initial stages and maintenance of chronic pain and the emergence of anxiety-like behaviors.
B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway.
TL;DR: Accumulating evidence demonstrates that GRP is a key neurotransmitter in pruriceptors for mediating histamine-independent itch and that BNP is an itch-selective peptide that acts as the first station of a dedicated neuronal pathway comprising a GRP-GRPR cascade for itch.
Pain Inhibits GRPR Neurons via GABAergic Signaling in the Spinal Cord.
Rita Bardoni,Kai Feng Shen,Hui Li,Hui Li,Joseph Jeffry,Devin M. Barry,Antonella Comitato,Yun-Qing Li,Zhou-Feng Chen +8 more
TL;DR: The role of GRPR neurons as a key circuit for itch transmission is strengthened and a spinal mechanism whereby pain inhibits itch by suppressing the function of GR PR neurons is illustrated.