Hugo Geerts
Janssen Pharmaceutica
78 Papers
922 Citations
Hugo Geerts is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Tau protein & Apoptosis. The author has an hindex of 28, co-authored 73 publications.
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Papers
Prominent Axonopathy in the Brain and Spinal Cord of Transgenic Mice Overexpressing Four-Repeat Human tau Protein
Kurt Spittaels,Chris Van den Haute,Jo Van Dorpe,Koen Bruynseels,Kris Vandezande,Isabelle Laenen,Hugo Geerts,Marc Mercken,Raf Sciot,Alfons Van Lommel,Ruth J. F. Loos,Fred Van Leuven +11 more
TL;DR: It is proved that merely increasing the concentration of the four-repeat tau protein isoform is sufficient to injure neurons in the central nervous system, without formation of intraneuronal neurofibrillary tangles.
Annexin V binding assay as a tool to measure apoptosis in differentiated neuronal cells
TL;DR: It is shown that the annexin V-binding assay is also applicable to differentiated neuronal cells with fragile neurite outgrowths, and when the cells are incubated with Annexin V prior to harvesting, the former cell populations can be separated from cells damaged during isolation.
237
Robust Autofocusing in Microscopy
Jan-Mark Geusebroek,Jan-Mark Geusebroek,Frans W. Cornelissen,Arnold W. M. Smeulders,Hugo Geerts +4 more
- 01 Jan 2000
TL;DR: In this paper, a robust and fast autofocus approach was proposed for a wide range of microscopic modalities and preparations, using convolution with the derivative of a Gaussian smoothing function.
203
Lateral diffusion and retrograde movements of individual cell surface components on single motile cells observed with Nanovid microscopy.
TL;DR: Nanovid microscopy, offering the possibility to observe the motion of individual specific cell surface components, provides a new and powerful tool to study the dynamic reorganization of the cell membrane during locomotion and in other biological contexts as well.
Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer’s disease
TL;DR: Cloned several murine tau isoforms can be assembled into paired helical filaments similar to those in Alzheimer's disease, using the same protocols as with human tau.
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