Huangming Xie
Massachusetts Institute of Technology
8 Papers
159 Citations
Huangming Xie is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Adipogenesis & microRNA. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Huangming Xie include Boston Children's Hospital & Genome Institute of Singapore.
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Papers
MicroRNA-125b is a novel negative regulator of p53
Minh T.N. Le,Cathleen Teh,Ng Shyh-Chang,Huangming Xie,Huangming Xie,Huangming Xie,Beiyan Zhou,Vladimir Korzh,Harvey F. Lodish,Harvey F. Lodish,Bing Lim,Bing Lim,Bing Lim +12 more
TL;DR: It is demonstrated that miR-125b, a brain-enriched microRNA, is a bona fide negative regulator of p53 in both zebrafish and humans and demonstrates that p53 gene expression is tightly regulated during development and during the stress response.
MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity
TL;DR: The remarkable inverse regulatory pattern for many miRNAs during adipogenesis and obesity has important implications for understanding adipose tissue dysfunction in obese mice and humans and the link between chronic inflammation and obesity with insulin resistance.
Mir193b–365 is essential for brown fat differentiation
Lei Sun,Huangming Xie,Huangming Xie,Huangming Xie,Marcelo A. Mori,Ryan Alexander,Bingbing Yuan,Shilpa M. Hattangadi,Shilpa M. Hattangadi,Qingqing Liu,C. Ronald Kahn,Harvey F. Lodish +11 more
TL;DR: It is demonstrated that a brown-fat-enriched miRNA cluster, MiR-193b–365, serves as an essential regulator for brown fat differentiation, in part by repressing myogenesis.
Targeting microRNAs in obesity
TL;DR: In this article, the authors summarize the current state of understanding of the roles of microRNAs in metabolic tissues under normal development and obese conditions, and discuss the potential use of miRNAs as therapeutic targets.
MiR-193b-365, a brown fat enriched microRNA cluster, is essential for brown fat differentiation
Lei Sun,Huangming Xie,Marcelo A. Mori,Ryan Alexander,Bingbing B. Yuan,Shilpa M. Hattangadi,Qingqing Liu,C. Ronald Kahn,Harvey F. Lodish +8 more
- 01 Jul 2011
TL;DR: It is demonstrated that a brown fat-enriched miRNA cluster, miR-193b-365, serves as an essential regulator for brown fat differentiation, in part by repressing myogenesis.
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