The formulae and biologically active ingredients of Chinese herbal medicines for the treatment of atopic dermatitis.

Atherosclerosis, a chronic luminal stenosis disorder occurred in large and medium arteries, is the principle pathological basis of cardiovascular diseases with the highest morbidity and mortality worldwide. In oriental countries, traditional Chinese medicine Cortex Moutan has been widely used for the treatment of atherosclerosis-related illnesses for thousands of years. Paeonol, a bioactive monomer extracted from Cortex Moutan, is an important pharmacological component responsible for the antiatherosclerotic effects. Numerous lines of findings have established that paeonol offers beneficial roles against the initiation and progression of atherosclerotic lesions through inhibiting proatherogenic processes, such as endothelium damage, chronic inflammation, disturbance of lipid metabolism, uncontrolled oxidative stress, excessive growth, and mobilization of vascular smooth muscle cells as well as abnormality of platelet activation. Investigations identifying the atheroprotective effects of paeonol present substantial evidence for potential clinical application of paeonol as a therapeutic agent in atherosclerosis management. In this review, we summarize the antiatherosclerotic actions by which paeonol suppresses atherogenesis and provide newly insights into its atheroprotective mechanisms and the future clinical practice.

/pdf/beneficial-effects-exerted-by-paeonol-in-the-management-of-agsy3cg6qj.pdf

Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis.

A review of the ethnobotany, phytochemistry and pharmacology of tree peony (Sect. Moutan)

Establishment of apoptotic regulatory network for genetic markers of colorectal cancer and optimal selection of traditional Chinese medicine target.

Deep eutectic solvents (DESs-)-ultrasonic-assisted extraction technology was used to evaluate and optimize the extraction process of paeoniflorin and paeonol in Moutan Cortex. First of all, 10 kinds of choline chloride-based DESs were selected as potential extraction solvents, and the DES extraction effect of choline chloride: lactic acid was determined to be the best. Then, single-factor experiments were conducted to explore the effects of DES composition (molar ratio, water content, and ratio of material to liquid) and ultrasonic treatment (ultrasonic power, extraction time, extraction temperature, and vortex time) on the yield of paeoniflorin and paeonol in Moutan Cortex. On this basis, the response surface method was used to optimize the process of ultrasonic-assisted extraction of paeoniflorin and paeonol from Moutan Cortex with DESs. The results showed that the optimum process parameters of DESs-ultrasonic-assisted extraction of paeoniflorin and paeonol from Moutan Cortex were as follows: molar ratio of choline chloride to lactic acid was 1 : 2, water content was 30%, ratio of material to liquid was 1 : 30 (g/mL), ultrasonic power was 300 W, extraction time was 33 min, extraction temperature was 50°C, and vortex time was 5 min. Under these conditions, the yield sum of paeoniflorin and paeonol in the obtained Moutan Cortex was 9.279 mg/g. The difference between the experimental value and the theoretical value was 0.333 mg/g. The results showed that the response surface method can simulate and predict the yield of paeoniflorin and paeonol in Moutan Cortex under different extraction conditions, and it was feasible to optimize the process parameters. The results of this study show that DES has great potential to replace traditional solvents in the extraction of active components of the Moutan Cortex. The study on the extraction of active components of traditional Chinese medicine by DES is helpful to expand the scope of the application of DES in traditional Chinese medicine.

Deep Eutectic Solvents (DESs)-Ultrasonic-Assisted Extraction of Paeoniflorin and Paeonol from Moutan Cortex

Cortex moutan radicis and its main components of paeonol has the functions of liver and kidney protection,regulating blood sugar level,anti-inflammation,antibacterial,resisting arrhythmia,anti-allergy,cardiovascular protection,nervous protection,immunity enhancement and so on.In addition,cortex moutan radicis aslo has other pharmacological effects on coagulation and hemostasis.The development of pharmacological reseach on cortex moutan radicis,will provide scientific basis for its clinical application and further development.

Pharmacological activities of cortex moutan radicis and its main components of paeonol

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Pharmacological activities of cortex moutan radicis and its main components of paeonol