The discovery of antidepressant drugs by computer-analyzed human cerebral bio-electrical potentials (CEEG).

Publisher Summary This chapter discusses results of some studies focusing on antidepressives and stimulants. In a preliminary study with depressed outpatients, imipramine and ketipramine were approximately equivalent in therapeutic effectiveness. A comparison of desipramine with a placebo in both endogenous and neurotic depression showed desipramine to be superior to placebo in patients with endogenous depression after 5 days, but no significant difference in response was noted in the neurotic patients. Clinical studies of iprindole showed that the time of onset of the therapeutic response was similar to that for other tricyclics but iprindole produced fewer troublesome side effects. Methylphenidate and magnesium pemoline were more effective than placebo in mildly depressed outpatients; however, pschiatric patients did not respond well to these stimulants. In a study dealing with a group of “neurophysiologic immature” inpatient children, minimal doses of methylphenidate produced favorable improvement in five of eight children. A clinical study of prolintane, a compound related to amphetamine, was conducted in fatigued volunteers. Prolintane (40 mg) was less effective than 2-amphetamine (20 mg) in producing definite stimulant, euphoriant, anorectic and sympathomimetic clinical effects.

Chapter 2. Antidepressives and Stimulants

Antidepressants and metabolites that block GABAA receptors coupled to 35S-t-butylbicyclophosphorothionate binding sites in rat brain

Clinical and quantitative electroencephalographical effects of MK 940.

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Clinical and quantitative electroencephalographical effects of MK 940.