Howard Cohen
8 Papers
Howard Cohen is an academic researcher. The author has contributed to research in topics: Epigenetics & Senescence. The author has an hindex of 5, co-authored 5 publications.
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Papers
Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
Steve Horvath,Junko Oshima,Junko Oshima,George M. Martin,Ake T. Lu,Austin Quach,Howard Cohen,Sarah Felton,Mieko Matsuyama,Donna Lowe,Sylwia Kabacik,James G. Wilson,Alexander P. Reiner,Anna Maierhofer,Julia Flunkert,Abraham Aviv,Lifang Hou,Andrea A. Baccarelli,Yun Li,James D. Stewart,Eric A. Whitsel,Luigi Ferrucci,Shigemi Matsuyama,Ken Raj +23 more
- 01 Jul 2018
TL;DR: A novel and highly robust DNAm age estimator for human fibroblasts, keratinocytes, buccal cells, endothelial cells, lymphoblastoid cells, skin, blood, and saliva samples that uncovered an epigenetic age acceleration with a magnitude below the sensitivity levels of other DNAm-based biomarkers.
The relationship between epigenetic age and the hallmarks of aging in human cells
Sylwia Kabacik,Donna Lowe,L. Fransen,Martin O. Leonard,Siew-Lan Ang,Christopher Whiteman,Sarah Corsi,Howard Cohen,Sarah Felton,Radhika Bali,Steve Horvath,Ken Raj +11 more
TL;DR: In this paper , the authors investigated whether epigenetic aging is the manifestation of one or more of the aging hallmarks previously identified, and they showed that although aging is distinct from cellular senescence, telomere attrition and genomic instability, it is associated with nutrient sensing, mitochondrial activity and stem cell composition.
Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression
Sylwia Kabacik,Steve Horvath,Howard Cohen,Ken Raj +3 more
- 17 Oct 2018
TL;DR: Employment of hTERT mutants revealed that neither telomere synthesis nor immortalisation is necessary for the continued increase in epigenetic age by these cells, and the extension of their lifespan is sufficient to support continued epigenetic ageing of the cell.
Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation
Steve Horvath,Ake T. Lu,Howard Cohen,Ken Raj +3 more
- 26 May 2019
TL;DR: It is reported here that epigenetic ageing is not affected by replicative senescence, telomere length, somatic cell differentiation, cellular proliferation rate or frequency and is instead retarded by rapamycin, the potent inhibitor of the mTOR complex which governs many pathways relating to cellular metabolism.
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Post-exposure persistence of nitric oxide upregulation in skin cells irradiated by UV-A
TL;DR: In this paper , the duration of nitric oxide release in skin cells after UV exposure is not well studied, with emphasis on UV-B mediated iNOS upregulation, peaking around 48 h post exposure.