Houming Wu
Chinese Academy of Sciences
4 Papers
10 Citations
Houming Wu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: BK channel & Gating. The author has an hindex of 3, co-authored 4 publications.
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Papers
Purification, characterization and sequence determination of BmKK4, a novel potassium channel blocker from Chinese scorpion Buthus martensi Karsch
TL;DR: The scorpion neurotoxin BmKK4 was purified from the venom of the Chinese scorpion Buthus martensi Karsch by a combination of gel-filtration, ion exchange and reversed phase chromatography and is the first isolated member of a new subfamily alpha-KTx17 of scorpion K(+) toxins.
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Interaction Sites between the Slo1 Pore and the NH2 Terminus of the β2 Subunit, Probed with a Three-residue Sensor
Hui Li,Jing Yao,Xiaotian Tong,Zhaohua Guo,Ying Wu,Liang Sun,Na Pan,Houming Wu,Tao Xu,Tao Xu,Jiuping Ding +10 more
TL;DR: It is identified that the NH2 terminus of β2-subunits interacts with the residues near the cytosolic superficial mouth of BK channels during inactivation, and it is suggested that the residue Ile-323 plays a dual role in interacting with theNH2 termini of β1-subunit and modulating the gating of Bk channels.
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Interaction Sites between the Slo1 Pore and the NH 2 Terminus of the 2 Subunit, Probed with a
Hui Li,Jing Yao,Xiaotian Tong,Zhaohua Guo,Ying Wu,Liang Sun,Houming Wu,Jiuping Ding +7 more
- 01 Jan 2007
TL;DR: It is identified that the NH2 terminus of 2-subunits interacts with the residues near the cytosolic superficial mouth of BK channels during inactivation, and it is suggested that the residue Ile-323 plays a dual role in interacting with the NH1 termini of wild-type2-subunit and modulating the gating of Bk channels.
BmP09, a "long chain" scorpion peptide blocker of BK channels.
Jing Yao,Xiang Chen,Hui Li,Yang Zhou,Yang Zhou,Lijun Yao,Lijun Yao,Gong Wu,Xiaoke Chen,Xiaoke Chen,Naixia Zhang,Zhuan Zhou,Zhuan Zhou,Tao Xu,Tao Xu,Houming Wu,Jiuping Ding +16 more
TL;DR: It is found that the toxin BmP09 specifically blocked large conductance Ca2+- and voltage-dependent K+ channels (BK) but not Na+ channels at a range of 100 nm concentration, and will be a more efficient tool for studying BK channels.